{"id":97991,"date":"2025-04-07T20:31:28","date_gmt":"2025-04-07T20:31:28","guid":{"rendered":"https:\/\/www.mymsd.ch\/it\/?post_type=product&#038;p=97991"},"modified":"2025-11-27T13:36:45","modified_gmt":"2025-11-27T13:36:45","slug":"efficacia","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/it\/products\/welireg\/ls004\/efficacia\/","title":{"rendered":"Efficacia"},"content":{"rendered":"\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--e06bfa04a2ff7aea26e0e3e65befe8a5\">Die Wirksamkeit und die Sicherheit von WELIREG\u00ae wurden in der Phase 2-Studie <strong>LITESPARK-004<\/strong> untersucht.<sup>1,2<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--489182c7e0b8fed366f5d09e5eb30176\" style=\"color:#123a8a\">Disegno dello studio<sup>2<\/sup><\/h2>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--8522c3b62bd645b542ac7083170ce6f9\">\n                    <img loading=\"lazy\" decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102110\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-Study-Design.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"448\"\n                alt=\"Disegno dello studio\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--97fe07a793d5c92c2b2b8cd60ac29836\"><em><mark class=\"has-inline-color has-black-color\">Adattato dall\u2019informazione professionale di WELIREG\u00ae<sup>1<\/sup> e Jonasch E, et al. , NEJM 2021.<sup>2<\/sup><br>a. La risposta secondo RECIST v1.1 \u00e8 stata definita come una riduzione \u2265 30% della somma dei diametri delle lesioni target, dove la somma dei diametri al basale \u00e8 stata utilizzata come riferimento.<sup>1,3<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--7c69cb0a96ceeaf5b018e4ef9a891663\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102111\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-Study-Population.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"555\"\n        loading=\"lazy\"        alt=\"popolazione in studio\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--e2b5d7ca6719ba9c30784e199325cede\"><em><mark class=\"has-inline-color has-black-color\">Adattato dall\u2019informazione professionale di WELIREG\u00ae<sup>1<\/sup> e Jonasch E, et al. , NEJM 2021.<sup>2<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-center mhh-mcn-v1-columns--35095cf8042dd71f2cd1e2639f8a13f1 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--09a7d9038cc1b6be2f768a9e5d26121e mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    \n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n<\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<h2 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--e0bb550b5057e233730735515db05267\" style=\"color:#123a8a\">Risultati a lungo termine dello studio di fase 2 LITESPARK-004 con un follow-up mediano di 49.9 (48.2 &#8211; 58.1) mesi<sup>4<\/sup><\/h2>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--d62c3b2414666402f6bf56c521a70065\">Lo studio LITESPARK-004, con un follow-up mediano di oltre 4 anni, ha dimostrato che WELIREG\u00ae ha un effetto antitumorale duraturo nei tumori associati alla VHL.<sup>4<\/sup><\/p>\n\n\n\n<ul class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--424b2bde6d87c263565afebcdcb151a4 mhh-mcn-list mhh-mcn-v2-clist--unordered mhh-mcn-v2-clist--unordered-dot\" dir=\"ltr\" lang=\"en-US\" start=\"1\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Il 75% (n = 46) dei\/delle pazienti ha subito un totale di 86 procedure di riduzione del tumore nei quattro anni precedenti l&#8217;inizio della terapia. Il 26% (n = 16) dei\/delle pazienti ha subito 18 procedure di riduzione del tumore dopo l&#8217;inizio del trattamento con WELIREG\u00ae.<sup>4<\/sup>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Il 59% (n = 36) dei\/delle pazienti era ancora in trattamento alla data di cut-off dei dati.<sup>4<\/sup>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Il profilo di sicurezza \u00e8 rimasto sostanzialmente invariato.<sup>4<\/sup>    <\/li>\n\n<\/ul>\n\n\n<div class=\"mhh-mcn-v1-accordion mhh-mcn-v1-accordion--20f3be8d0f6b4f98eec592597669a0d2 mhh-mcn-v1-accordion--multiple\" data-configuration=\"{&quot;variation&quot;:&quot;multiple&quot;,&quot;speed&quot;:0,&quot;hasFirstItemExpanded&quot;:false}\"    dir=\"ltr\"    lang=\"en-US\">\n    \n\n<section\n    id=\"accordion-6a2940662afac\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--ea3444b2ae3954f31214749fae872a0e mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a2940662afac-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a2940662afac-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--e3bdd53166acdb64e1e94372395713a9\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-102004\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/Icon_Kidneys.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: Emangioblastomi dell\u2019SNC<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/it\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a2940662afac-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a2940662afac-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--faeb73a2fea2d02456897ff91ce4b061\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102108\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-RCC-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: Emangioblastomi dell\u2019SNC\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-black-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--5d0e0818c7c14575e3b8f84026f9874b\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Dati insufficienti per la valutazione della risposta secondo RECIST v1.1.<br>+ indica che la risposta \u00e8 ancora in corso.<br>Tempo mediano di follow-up dalla prima dose fino alla data di cut-off dei dati (3 aprile 2023): 49.9 mesi (intervallo: 48.2\u201358.1).<\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--100344840b3cd06c37245fded38a1759\"><strong>WELIREG\u00ae ha ridotto le dimensioni degli RCC associati alla VHL<sup>4<\/sup><\/strong><\/h5>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--f30ce9bce8aad52f1d8f77937ae05823\">BIn 41 pazienti (67%) si \u00e8 verificata una riduzione della lesione target.<sup>4<\/sup><\/p>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--0d206ebd3bb4dd7757ebcfcb6a6853ed\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102106\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-RCC-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae ha ridotto le dimensioni degli RCC associati alla VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6e3c443241f1bb56360dc48a61d27a82\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--667300f108d5c909632ca96c8e8e93c0\"><strong>Durata del trattamento con WELIREG\u00ae nelle lesioni target di RCC associate alla VHL, miglior tasso di risposta globale e stato della progressione della malattia<sup>4<\/sup><\/strong><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--eb824087552b91487ffc56606431b457\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102109\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-RCC-Treatment-Duration.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"580\"\n        loading=\"lazy\"        alt=\"Durata del trattamento con WELIREG\u00ae nelle lesioni target di RCC associate alla VHL, miglior tasso di risposta globale e stato della progressione della malattia\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6e3c443241f1bb56360dc48a61d27a82\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--ece24c0a9e8bcad9ae1e55c1e65c0d8a\"><strong>Stima di Kaplan-Meier della DOR e della PFS negli RCC associati alla VHL<sup>4<\/sup><\/strong><sup><strong>,a<\/strong><\/sup><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--58bcba412838dcdf07ea3dade6995e7b\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102107\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-RCC-DOR-PFS.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"387\"\n        loading=\"lazy\"        alt=\"Stima di Kaplan-Meier della DOR e della PFS negli RCC associati alla VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--5c246b7ae18271caed89af13098cc0ed\"><em><mark class=\"has-inline-color has-black-color\">Grafici adattati da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. secondo RECIST v1.1 valutata da IRC.<br>+ indica che la risposta \u00e8 ancora in corso.<\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a2940662c1ae\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--514c8cb50be7b68894f921b1490899ee mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a2940662c1ae-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a2940662c1ae-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--9bbb80ad57d186dcfb57a2ec22a52ee8\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-102005\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/Icon_Brain.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: Emangioblastomi dell\u2019SNC<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/it\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a2940662c1ae-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a2940662c1ae-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--ad02217bc347e75579f2ee04ec8595b4\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102102\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-CNS-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: Emangioblastomi dell\u2019SNC\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--0686246183977cd4893c76886b6e48ef\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Dati insufficienti per la valutazione della risposta secondo RECIST v1.1.<br>+ indica che la risposta \u00e8 ancora in corso.<br>Tempo mediano di follow-up dalla prima dose fino alla data di cut-off dei dati (3 aprile 2023): 49.9 mesi (intervallo: 48.2\u201358.1).<\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--d1ea4adea517f4dc9afbf4c30e601669\"><strong>WELIREG\u00ae ha ridotto le dimensioni del tumore degli emangioblastomi associati alla VHL<sup>4<\/sup><\/strong><sup>,a<\/sup><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--afe002134b9c4fb5144764e1bbd65481\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102101\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-CNS-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae ha ridotto le dimensioni del tumore degli emangioblastomi associati alla VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--fc67c212be2f1de2c6fb54dd44aba478\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Per 30 dei 50 pazienti erano disponibili dati valutabili dopo l&#8217;inizio dello studio con malattia misurabile; 4 pazienti hanno ottenuto una CR, tra cui 3 pazienti che, all&#8217;inizio dello studio, avevano solo una malattia non misurabile, e 3 pazienti hanno avuto una PD, tra cui 2 con sola malattia non misurabile all&#8217;inizio dello studio (non mostrati nel diagramma a cascata). Data di cut-off dei dati: 3 aprile 2023.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a2940662d28b\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--64b24c1db927c2a88b19471def803fdf mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a2940662d28b-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a2940662d28b-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--060886131265fd7a39400751f298b474\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-102006\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/Icon_Pancreas.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: pNET<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/it\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a2940662d28b-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a2940662d28b-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--47fa1f61fba26df1e04b5eba9744694d\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102105\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-pNET-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"Risultati dell\u2019analisi di follow-up estesa dopo 49.9 (48.2 \u2013 58.1) mesi: pNET\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--95d5d7ebf038af1fd706a0ac08c45437\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Dati insufficienti per la valutazione della risposta secondo RECIST v1.1.<br>b. I dati si riferiscono a tutte le lesioni pancreatiche (n = 61), comprese sia le lesioni pNET che quelle non pNET.<br>+ indica che la risposta \u00e8 ancora in corso.<br>Tempo mediano di follow-up dalla prima dose fino alla data di cut-off dei dati (3 aprile 2023): 49.9 mesi (intervallo: 48.2\u201358.1).<\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--6b75628964a2400fa5b1fb82a848a73e\"><strong>WELIREG\u00ae ha ridotto le dimensioni del tumore dei pNET associati alla VHL<sup>4<\/sup><\/strong><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--31e4ee15d3916ff33792df4ecc703e90\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102104\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-pNET-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae ha ridotto le dimensioni del tumore dei pNET associati alla VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6e3c443241f1bb56360dc48a61d27a82\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a2940662dde5\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--9e5deda2b730a688a37285588f70fe64 mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a2940662dde5-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a2940662dde5-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--deeb290c8d1a255ec16822a33972fee3\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-102100\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/Icon_Operation.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                Operazioni correlate alla VHL<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/it\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a2940662dde5-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a2940662dde5-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--4a782aa129719b94ec3b1de722151aaf\">WELIREG\u00ae ha portato a una riduzione degli interventi chirurgici correlati alla VHL.<sup>4<\/sup><\/p>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--f0497ea20aaf5806daba90c22c90bdb2\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-102103\"\n        src=\"https:\/\/www.mymsd.ch\/it\/wp-content\/uploads\/sites\/47\/2025\/04\/I-WELIREG-LS004-Operations.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"501\"\n        loading=\"lazy\"        alt=\"Operazioni correlate alla VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6e3c443241f1bb56360dc48a61d27a82\"><em><mark class=\"has-inline-color has-black-color\">Adattato da Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-center mhh-mcn-v1-columns--35095cf8042dd71f2cd1e2639f8a13f1 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--09a7d9038cc1b6be2f768a9e5d26121e mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    \n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n<\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--6c0f5b0106e7ed3304508ccaad76ef2b mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--6d4fa191da847a5b495c163e1937a612 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--26ec21906b4635b45dad8d279b4552ba mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--92b6f6370768c7c6f876273c47aa6ec4 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-top mhh-mcn-v1-columns--408bf226423909a713bac7946b34ca5b mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--c81b7ac01531cf2e7dceb28402da9afc mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h3 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color has-link-color wp-elements-010a97bf3634c74fb7c8b7524c95d3c4  mhh-mcn-v1-heading mhh-mcn-v1-heading--6c07afc4705dc28f9217057e95372705\" style=\"color:#123a8a\"><strong>I risultati a lungo termine dello studio <span class=\"no-text-breaking\">LITESPARK-004<\/span> (analisi di follow-up a 49.9 (48.2-58.1) mesi) sostengono ulteriormente l&#8217;efficacia WELIREG\u00ae negli RCC, negli emangioblastomi dell&#8217;SNC e nei pNET associati alla VHL.<sup>4<\/sup><\/strong><\/h3>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--4a91073cfc5134869172824e6108f655\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--67a7fe7ddd4f88e8ea0fe998e28c77df\" href=\"mailto:%20dpoc.switzerland@msd.com\" target=\"_self\" aria-label=\"All&#039;occorrenza, \u00e8 possibile richiedere copie delle pubblicazioni degli studi all&#039;indirizzo dpoc.switzerland@msd.com.\">\n                    <span class=\"mhh-mcn-v1-link__label\">All&#8217;occorrenza, \u00e8 possibile richiedere copie delle pubblicazioni degli studi all&#8217;indirizzo dpoc.switzerland@msd.com.<\/span>\n                <\/a><\/div>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--cf001819abe904358b67c828e1a711ac mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--aa6eb7d24967fbdf5f46623b0f8527fb mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--414023fc8dcfb40c6c995fedc694b7a0\"><em><mark class=\"has-inline-color has-black-color\"><strong>Abbreviazioni<\/strong>:<\/mark><\/em><\/h5>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-object-object-font-size has-border-color has-has-red-border-color-border-color has-black-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--4899b791a50bfb6fe91174ece1e28c67\"><em><mark class=\"has-inline-color has-black-color\"><strong>CR<\/strong>: risposta completa (complete response); <strong>DOR<\/strong>: durata della risposta (duration of response); <strong>ECOG PS<\/strong>: Eastern Cooperative Oncology Group performance status; <strong>IRC<\/strong>: commissione indipendente di esperti (independent review committee); <strong>ORR<\/strong>: tasso di risposta globale (overall response rate); <strong>PD<\/strong>: malattia progressiva (progressive disease); <strong>pNET<\/strong>: tumore neuroendocrino del pancreas (pancreatic neuroendocrine tumor); <strong>PR<\/strong>: risposta parziale (partial response); <strong>RCC<\/strong>: carcinoma a cellule renali (renal cell carcinoma); <strong>RECIST v1.1<\/strong>: Response Evaluation Criteria In Solid Tumors v1.1; <strong>SD<\/strong>: malattia stabile (stable disease) ; <strong>SNC<\/strong>: sistema nervoso centrale; <strong>TTR<\/strong>: tempo fino alla risposta (time to response); <strong>TTS<\/strong>: tempo fino all\u2019operazione (time to surgery); <strong>VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--b8d3cff3cab56efdcfc87c3327544997 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--fd1ff3ae32764b466d38641964924925 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--2d13f7e932621573f3c57e11dc20430a\"><em><mark class=\"has-inline-color has-black-color\"><strong>Riferimenti bibliografici:<\/strong> <\/mark><\/em><\/h5>\n\n\n\n<ol class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--ae273ed7fc57a3d310dcd02fecfc5812 mhh-mcn-list mhh-mcn-v2-clist--ordered mhh-mcn-v2-clist--ordered-decimal\" dir=\"ltr\" lang=\"en-US\" start=\"1\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Informazione professionale di WELIREG\u00ae (belzutifan)<mark class=\"has-inline-color has-gray-700-color\"><mark class=\"has-inline-color has-gray-700-color\">,\u00a0<a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=DE&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swis<\/a><a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=IT&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">smedicinfo.ch<\/a><\/mark><\/mark>, ultima consultazione il 07.03.2025.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Jonasch E, et al. Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. N Engl J Med. 2021;385:2036\u2009\u2013\u20092046. DOI: 10.1056\/NEJMoa2103425.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Eisenhauer EA, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228 \u2013 247.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Srinivasan R, et al. Belzutifan, a Hypoxia-Inducible Factor-2\u03b1 Inhibitor, for von Hippel-Lindau Disease\u2013Associated Neoplasms: Long-Term Results of the Phase 2 LITESPARK-004 Study. Presented at the American Association for Cancer Research (AACR) Annual Meeting; San Diego, California; April 5 \u2013 10, 2024.<\/em>    <\/li>\n\n<\/ol>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--ebccbd3cb151a64d7c7b8020ba8fbc90\"><mark class=\"has-inline-color has-black-color\">\u25bc <em>Questo medicamento \u00e8 soggetto a monitoraggio addizionale. Per ulteriori informazioni, vedere l\u2019informazione professionale di WELIREG\u00ae su  <a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=IT&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo.ch<\/a>.<\/em><br><br><em>Prima della prescrizione, consultare l\u2019informazione professionale completa pubblicata sul sito \u00a0<a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=IT&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo.ch<\/a>.<\/em><\/mark><\/p>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--d45c0a02c1c8d3ab434885d14fc893f8\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--8e36526b1be316f1b5bf47c7ff30bf28 mhh-mcn-v1-link--is-variation mhh-mcn-v1-link--button-custom\" href=\"https:\/\/swissmedicinfo.ch\/showText.aspx?textType=FI&#038;lang=IT&#038;authNr=68531&#038;supportMultipleResults=1\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Informazione professionale di WELIREG\u00ae\">\n                    <span class=\"mhh-mcn-v1-link__label\">Informazione professionale di WELIREG\u00ae<\/span>\n                <\/a><\/div>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--fa89c056680883a2ec9706c4eaef9fe8\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--937794a7295f4297d1457c44d974563a mhh-mcn-v1-link--is-variation mhh-mcn-v1-link--button-custom\" href=\"https:\/\/www.mymsd.ch\/it\/succinctstatement\/welireg\/\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Informazione professionale breve di WELIREG\u00ae\">\n                    <span class=\"mhh-mcn-v1-link__label\">Informazione professionale breve di WELIREG\u00ae<\/span>\n                <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nella terapia con WELIREG\u00ae \u00e8 stata osservata una risposta obiettiva in tre tumori associati a VHL.<\/p>\n","protected":false},"author":202221,"featured_media":102129,"parent":102041,"menu_order":4,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[],"related_products":"","fact_sheet":null,"scientific_title":"","job_code":"","banner":102114,"primary_logo":null,"secondary_logo":null,"icon":null,"primary_tag":1017,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[286,312],"tags":[1017,1018],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[501],"ga4_page_businessunit":[507],"ga4_page_campaign":[],"ga4_page_content_purpose":[536],"ga4_page_customer_journey_stage":[556],"ga4_page_customer_specialty":[588],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[713],"ga4_page_product":[722],"ga4_page_region":[946],"ga4_page_therapeuticarea":[982],"tx-therapeutic-area":[280,229],"tx-product":[1016],"tx-pathology":[1019],"tx-content-type":[285,313],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-97991","product","type-product","status-publish","has-post-thumbnail","hentry","category-indicazioni","category-informazioni-sul-prodotto","tag-welireg","tag-welireg-2"],"yoast_head":"<!-- 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