{"id":97954,"date":"2025-04-07T20:29:44","date_gmt":"2025-04-07T20:29:44","guid":{"rendered":"https:\/\/www.mymsd.ch\/it\/?post_type=product&p=97954"},"modified":"2025-11-30T23:01:39","modified_gmt":"2025-11-30T23:01:39","slug":"che-cose-la-vhl","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/it\/products\/welireg\/ls004\/che-cose-la-vhl\/","title":{"rendered":"Che cos\u2019\u00e8 la VHL?"},"content":{"rendered":"
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La malattia di VHL<\/strong> \u00e8 una malattia ereditaria multi-organo a trasmissione autosomica dominante, caratterizzata da una crescita cellulare anomala. \u00c8 causata da mutazioni genetiche del gene oncosoppressore VHL.1<\/sup><\/p>\n\n\n\n

I tumori che si sviluppano sono spesso benigni, ma con la crescita tumorale possono causare sintomi a seconda della localizzazione. Tuttavia, alcuni tumori possono degenerare. Questi includono tumori nei reni e nel pancreas.1<\/sup><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

La malattia di VHL pu\u00f2 causare tumori nel sistema nervoso centrale, nel pancreas e nei reni.1<\/sup><\/h2>\n\n\n\n
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\n \"Pazienti\n <\/figure>\n\n<\/div>\n\n\n
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Pazienti con la VHL spesso sviluppano ulteriori tumori, tra i quali:1<\/sup><\/h3>\n\n\n
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\n \"Emangioblastomi:\n <\/figure>\n\n<\/div>\n\n\n
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Emangioblastomi: retina<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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Tumori del sacco endolinfatico: orecchio interno<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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\n \"Feocromocitomi:ghiandole\n <\/figure>\n\n<\/div>\n\n\n
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Feocromocitomi:ghiandole surrenali<\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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Frequenza delle lesioni e et\u00e0 media al momento della loro comparsa nelle persone affette da VHL1,2<\/sup><\/mark><\/h3>\n\n\n
\n \"Frequenza\n <\/figure>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n <\/div>\n<\/section>\n\n\n\n
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\n \n Vedere il meccanismo d’azione di WELIREG\u00ae <\/span>\n <\/a><\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n <\/div>\n<\/section>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n
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\n \n All’occorrenza, \u00e8 possibile richiedere copie delle pubblicazioni degli studi all’indirizzo dpoc.switzerland@msd.com.<\/span>\n <\/a><\/div>\n\n\n\n
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Abbreviazioni<\/strong>:<\/mark><\/em><\/h5>\n\n\n\n

pNET<\/strong>: tumori neuroendocrini del pancreas (pancreatic neuroendocrine tumor); RCC<\/strong>: carcinoma a cellule renali (renal cell carcinoma); SNC<\/strong>: sistema nervoso centrale; VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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Riferimenti bibliografici:<\/strong> <\/mark><\/em><\/h5>\n\n\n\n
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  1. \n Varshney N, et al. A review of von Hippel-Lindau syndrome. J Kidney Cancer VHL. 2017;4(3):20 \u2013 29. doi:10.15586\/jkcvhl.2017.88.<\/em> <\/li>\n\n\n
  2. \n Ganeshan D, et al. Tumors in von Hippel-Lindau syndrome: from head to toe \u2013 Comprehensive state-of- the-art review. RadioGraphics. 2018;38(3):849 \u2013 866.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Questo medicamento \u00e8 soggetto a monitoraggio addizionale. Per ulteriori informazioni, vedere l\u2019informazione professionale di WELIREG\u00ae su www.swissmedicinfo.ch<\/a>.<\/em>
    <\/mark>
    Prima della prescrizione, consultare l\u2019informazione professionale completa pubblicata sul sito \u00a0    www.swissmedicinfo.ch<\/a>.<\/mark><\/em><\/p>\n\n\n

    \n \n Informazione professionale di WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Informazione professionale breve di WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    La malattia di VHL pu\u00f2 causare tumori nel sistema nervoso centrale, nel pancreas e nei reni.<\/p>\n","protected":false},"author":202221,"featured_media":102062,"parent":102041,"menu_order":2,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[],"related_products":"","fact_sheet":null,"scientific_title":"","job_code":"","banner":102061,"primary_logo":null,"secondary_logo":null,"icon":null,"primary_tag":1017,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[286,311],"tags":[1017,1018],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[501],"ga4_page_businessunit":[507],"ga4_page_campaign":[],"ga4_page_content_purpose":[536],"ga4_page_customer_journey_stage":[556],"ga4_page_customer_specialty":[588],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[713],"ga4_page_product":[722],"ga4_page_region":[946],"ga4_page_therapeuticarea":[982],"tx-therapeutic-area":[280,229],"tx-product":[1016],"tx-pathology":[1019],"tx-content-type":[],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-97954","product","type-product","status-publish","has-post-thumbnail","hentry","category-indicazioni","category-oncology","tag-welireg","tag-welireg-2"],"yoast_head":"\nChe 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