{"id":102015,"date":"2025-08-22T07:02:08","date_gmt":"2025-08-22T07:02:08","guid":{"rendered":"https:\/\/www.mymsd.ch\/it\/?post_type=product&p=102015"},"modified":"2026-02-20T08:04:09","modified_gmt":"2026-02-20T08:04:09","slug":"meccanismo-dazione","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/it\/products\/welireg\/meccanismo-dazione\/","title":{"rendered":"Meccanismo d\u2019azione"},"content":{"rendered":"\n

Come agisce WELIREG\u00ae?<\/h1>\n\n\n\n

WELIREG\u00ae \u00e8 un inibitore del\u2019HIF-2\u03b1 che agisce nel nucleo cellulare e pu\u00f2 ridurre la trascrizione di specifici geni bersaglio che favoriscono la crescita di alcuni tumori.1<\/sup><\/p>\n\n\n\n

In condizioni di carenza di ossigeno, l’HIF-2\u03b1 attiva dei geni che promuovono la proliferazione cellulare, l’angiogenesi e la crescita tumorale. Normalmente, l’HIF-2\u03b1 viene degradato dalla proteina VHL. In condizioni di ipossia o in presenza di una proteina VHL difettosa, l’HIF-2\u03b1 si accumula e si stabilizza, migra nel nucleo cellulare dove interagisce con l’HIF-1\u03b2, attivando cos\u00ec dei geni che favoriscono la crescita. WELIREG\u00ae impedisce l’interazione HIF-2\u03b1\/HIF-1\u03b2 e inibisce quindi l’attivazione di questi geni bersaglio.1<\/sup><\/p>\n\n\n\n

WELIREG\u00ae \u00e8 indicato per determinati tumori associati alla malattia di VHL e per determinati carcinomi renali avanzati (aRCC).1<\/sup><\/p>\n\n\n

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WELIREG\u00ae pu\u00f2 bloccare l’interazione dell\u2019HIF-2\u03b1 con l\u2019HIF-1\u03b2, con conseguente riduzione della trascrizione e dell’espressione dei geni bersaglio di HIF-2\u03b1.1<\/sup><\/h2>\n\n\n
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\n \n All’occorrenza, \u00e8 possibile richiedere copie delle pubblicazioni degli studi all’indirizzo dpoc.switzerland@msd.com.<\/span>\n <\/a><\/div>\n\n\n\n
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Abbreviazioni<\/strong>:<\/em><\/h5>\n\n\n\n

aRCC<\/strong>: carcinoma a cellule renali avanzato (advanced renal cell carcinoma) ; HIF<\/strong>: fattore inducibile dall’ipossia (hypoxia-inducible factor); VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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Riferimenti bibliografici:<\/strong> <\/em><\/h5>\n\n\n\n
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  1. \n Informazione professionale di WELIREG\u00ae (belzutifan),\u00a0www.swis<\/a>smedicinfo.ch<\/a><\/mark><\/mark>, ultima consultazione il 22.08.2025.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Questo medicamento \u00e8 soggetto a monitoraggio addizionale. Per ulteriori informazioni, vedere l\u2019informazione professionale di WELIREG\u00ae su www.swissmedicinfo.ch<\/a>.<\/em>

    Prima della prescrizione, consultare l\u2019informazione professionale completa pubblicata sul sito      www.swissmedicinfo.ch<\/a>.<\/em><\/p>\n\n\n

    \n \n Informazione professionale di WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Informazione professionale breve di WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    WELIREG\u00ae \u2013 Un inibitore di HIF-2\u03b1<\/p>\n","protected":false},"author":202221,"featured_media":103094,"parent":101996,"menu_order":2,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[],"related_products":"","fact_sheet":null,"scientific_title":"","job_code":"","banner":103095,"primary_logo":null,"secondary_logo":null,"icon":null,"primary_tag":1017,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[],"tags":[1017,1018],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[501],"ga4_page_businessunit":[507],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[713],"ga4_page_product":[],"ga4_page_region":[],"ga4_page_therapeuticarea":[],"tx-therapeutic-area":[280,229],"tx-product":[1016],"tx-pathology":[413,1019],"tx-content-type":[285],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-102015","product","type-product","status-publish","has-post-thumbnail","hentry","tag-welireg","tag-welireg-2"],"yoast_head":"\nMeccanismo 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