{"id":103156,"date":"2025-08-25T11:46:16","date_gmt":"2025-08-25T11:46:16","guid":{"rendered":"https:\/\/www.mymsd.ch\/it\/?page_id=103156"},"modified":"2026-02-04T09:36:06","modified_gmt":"2026-02-04T09:36:06","slug":"isentress","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/it\/succinctstatement\/isentress\/","title":{"rendered":"Short prescribing information ISENTRESS\u00ae (Raltegravir)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--5404254f400998e22d40284659e510f9\"><mark class=\"has-inline-color has-teal-500-color\">Short prescribing information ISENTRESS\u00ae (Raltegravir)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--f47b6501d82fe86f2f528a07ca368e51\"><strong>ISENTRESS\u00ae (Raltegravir): C:<\/strong> Raltegravir; <strong>I: <\/strong>For treatment of human immunodeficiency virus (HIV-1) infection, in combination with antiretroviral medications; <strong>D:<\/strong> <em>Adults:<\/em> 600 mg: 1x daily 1200 mg (2&#215;600 mg) in treatment-na\u00efve patients or treatment-experienced patients, stable on 400 mg 2x daily, without prior virologic treatment failure, and virologically suppressed for at least 6 Mt on 400 mg 2x daily as part of initial HIV treatment. 400 mg: 2x daily in treatment-naive or -experienced patients. Formulations are not bioequivalent, so do not substitute 400 mg tablet for 600 mg. <em>Children\/Adolescents:<\/em> 400 mg: 2x daily if bw \u2265 25 kg. <em>Impaired renal function: <\/em>no dose adjustment. <em>Mildly to moderately impaired hepatic function:<\/em> no dose adjustment; <strong>CI:<\/strong> Hypersensitivity to ingredients; <strong>Pr:<\/strong> Risk of sexual transmission of HIV cannot be excluded if prescribed ART is not taken regularly and\/or viral suppression is not achieved and maintained. <em>HIV and hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfection:<\/em> Limited data available. <em>Osteonecrosis:<\/em> cases reported; in case of joint aches and pain, joint stiffness or difficulty in movement consult physician. <em>Serious skin reactions and hypersensitivity reactions:<\/em> Serious, potentially life-threatening and fatal skin reactions possible with concomitant use with drugs associated with such reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) &#8211; immediate discontinuation and adequate treatment may be required.; <strong>DDI:<\/strong> 400 mg: caution with strong UGT1A1 inducers. 600 mg: coadministration with UGT1A1 inhibitors and strong UGT1A1 inducers not recommended. Antacids (Al- and\/or Mg-containing; and CaCO3-containing at 600 mg): coadministration not recommended.; <strong>P\/L<\/strong> 400 mg 2x daily: Can be used during pregnancy if clinically necessary; 600 mg: Limited data available. Breastfeeding is not recommended.; <strong>UDE: <\/strong>400 mg and 600 mg: comparable incidence of serious clinical UDE. Pretreated patients: Drug-related \u2265 2%: diarrhea, headache. Treatment-naive patients: Drug-related \u2265 2%: diarrhea, nausea, fatigue, dizziness, headache, insomnia, rash, maculopapular rash; <strong>P:<\/strong> Bottles of 60 pieces: film-coated tablets: 400 mg and 600 mg.<strong> DC:<\/strong> A. <strong>MHA:<\/strong> MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, 6005 Lucerne, Switzerland. (V3.0); CH-MFA-00004.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--6ae685822eb12eb81b8ca49a8147a133\"><em><mark class=\"has-inline-color has-gray-700-color\">Before prescribing please consult the full prescribing information published on the homepage of Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=IT&amp;authNr=58267\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/mark><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Short prescribing information ISENTRESS\u00ae (Raltegravir) ISENTRESS\u00ae (Raltegravir): C: Raltegravir; I: For treatment of human immunodeficiency virus (HIV-1) infection, in combination 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