{"id":99751,"date":"2025-04-07T20:03:24","date_gmt":"2025-04-07T20:03:24","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?post_type=product&p=99751"},"modified":"2025-12-02T01:55:09","modified_gmt":"2025-12-02T01:55:09","slug":"ls004","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/fr\/products\/welireg\/ls004\/","title":{"rendered":"WELIREG\u00ae pour la VHL"},"content":{"rendered":"\n

Le prix Nobel de m\u00e9decine 2019 a r\u00e9compens\u00e9 la d\u00e9couverte d’un m\u00e9canisme physiologique central par lequel les cellules d\u00e9tectent la teneur en oxyg\u00e8ne de leur environnement et y r\u00e9agissent. Ce syst\u00e8me de r\u00e9gulation comprend les prot\u00e9ines induites par l’hypoxie (HIF), la prot\u00e9ine Von Hippel-Lindau (VHL) et l’\u00e9rythropo\u00ef\u00e9tine (EPO).2<\/sup> Ces d\u00e9couvertes fondamentales sont d\u00e9terminantes pour le principe actif de WELIREG\u00ae.1<\/sup><\/p>\n\n\n

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WELIREG\u00ae peut permettre de nouvelles approches th\u00e9rapeutiques pour certaines tumeurs associ\u00e9es \u00e0 la maladie de VHL.1<\/sup><\/h2>\n\n\n
\n \n Vers le mode d\u2019action<\/span>\n <\/a><\/div>\n\n\n
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WELIREG\u00ae en monoth\u00e9rapie est indiqu\u00e9 pour le traitement des patients adultes atteints de la maladie de von Hippel-Lindau (VHL) qui n\u00e9cessitent une th\u00e8rapie pour des carcinomes \u00e0 cellules r\u00e9nales (CCR) associ\u00e9s \u00e0 VHL, des h\u00e9mangioblastomes du syst\u00e8me nerveux central (SNC) ou des tumeurs neuroendocrines pancr\u00e9atiques (TNEp), et qui ne n\u00e9cessitent pas d\u2019intervention chirurgicale imm\u00e9diate.1,a<\/sup>
Aucune donn\u00e9e n\u2019est disponible sur les tumeurs m\u00e9tastatiques associ\u00e9es \u00e0 VHL.1<\/sup><\/mark><\/p>\n\n\n\n

a.<\/strong> En raison de donn\u00e9es cliniques incompl\u00e8tes au moment de l\u2019examen de la demande, ces indications sont autoris\u00e9es pour une dur\u00e9e limit\u00e9e (art. 9a LPTh). L\u2019autorisation \u00e0 dur\u00e9e limit\u00e9e est imp\u00e9rativement li\u00e9e \u00e0 la satisfaction de charges en temps opportun. Une fois ces charges satisfaites, l\u2019autorisation \u00e0 dur\u00e9e limit\u00e9e pourra \u00eatre transform\u00e9e en autorisation ordinaire.1<\/sup><\/mark><\/em><\/p>\n\n <\/div>\n<\/section>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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\n \"welireg\"\n\n <\/figure>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n
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\n \n Des exemplaires des publications de l’\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.<\/span>\n <\/a><\/div>\n\n\n\n
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Abr\u00e9viations<\/strong>:<\/em><\/h5>\n\n\n\n

CCR<\/strong>: carcinome a cellules renales; EPO:<\/strong> \u00e9rythropo\u00ef\u00e9tine; HIF<\/strong>: facteur induit par l’hypoxie (hypoxia-inducible factor); SNC<\/strong>: syst\u00e8me nerveux central; TNEp<\/strong>: tumeurs neuroendocrines du pancr\u00e9as; VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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R\u00e9f\u00e9rences:<\/strong> <\/em><\/h5>\n\n\n\n
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  1. \n Information professionnelle de WELIREG\u00ae (Belzutifan),\u00a0www.swissmedicinfo.ch<\/a><\/mark><\/mark>, derni\u00e8re consultation le 07.03.2025.<\/em> <\/li>\n\n\n
  2. \n The Nobel Prize. Nobel Prize in Physiology or Medicine 2019: Scientific Background. How cells sense and adapt to oxygen availability. Available from: URL: https:\/\/www.nobelprize.org\/prizes\/medicine\/2019\/advanced-information\/<\/a>; derni\u00e8re consultation le 07.03.2025.<\/em> <\/li>\n\n\n
  3. \n Narayan V, Jonasch E. Systemic therapy development in von Hippel\u2013Lindau disease: an outsized contribution from an orphan disease. Cancers (Basel). 2022; 14(21):5313.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Ce m\u00e9dicament fait l’objet d’une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l\u2019information professionnelle de WELIREG\u00ae disponible sous www.swissmedicinfo.ch<\/a>.<\/em>

    Avant la prescription, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur     www.swissmedicinfo.ch<\/a>.<\/em><\/p>\n\n\n

    \n \n Information professionnelle de WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    Le prix Nobel de m\u00e9decine 2019 a r\u00e9compens\u00e9 la d\u00e9couverte d’un m\u00e9canisme physiologique central par lequel les cellules d\u00e9tectent la 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