{"id":99729,"date":"2025-08-22T06:48:17","date_gmt":"2025-08-22T06:48:17","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?post_type=product&p=99729"},"modified":"2026-02-20T08:03:39","modified_gmt":"2026-02-20T08:03:39","slug":"mecanisme-daction","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/fr\/products\/welireg\/mecanisme-daction\/","title":{"rendered":"M\u00e9canisme d\u2019action"},"content":{"rendered":"\n

Comment agit WELIREG\u00ae?<\/h1>\n\n\n\n

WELIREG\u00ae est un inhibiteur de HIF-2\u03b1 qui agit dans le noyau cellulaire et peut r\u00e9duire la transcription de certains g\u00e8nes cibles qui favorisent la croissance de certaines tumeurs.1<\/sup><\/p>\n\n\n\n

En cas de manque d’oxyg\u00e8ne, HIF-2\u03b1 active des g\u00e8nes qui favorisent la prolif\u00e9ration cellulaire, l’angiogen\u00e8se et la croissance tumorale. Normalement, HIF-2\u03b1 est d\u00e9grad\u00e9 par la prot\u00e9ine VHL. Dans des conditions hypoxiques ou en cas de d\u00e9ficience de la prot\u00e9ine VHL, HIF-2\u03b1 s’accumule et se stabilise, migre vers le noyau cellulaire o\u00f9 il interagit avec HIF-1\u03b2 et active ainsi des g\u00e8nes favorisant la croissance. WELIREG\u00ae emp\u00eache l’interaction HIF-2\u03b1\/HIF-1\u03b2 et inhibe ainsi l’activation de ces g\u00e8nes cibles.1<\/sup><\/p>\n\n\n\n

WELIREG\u00ae est indiqu\u00e9 pour certaines tumeurs associ\u00e9es \u00e0 la maladie de VHL et pour certains carcinomes \u00e0 cellules r\u00e9nales (CCR) avanc\u00e9s.1<\/sup><\/p>\n\n\n

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WELIREG\u00ae peut bloquer l\u2019interaction du HIF-2\u03b1 avec le HIF-1\u03b2, ce qui entra\u00eene une r\u00e9duction de la transcription et de l\u2019expression des g\u00e8nes cibles de HIF-2\u03b1.1<\/sup><\/h2>\n\n\n
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\n \n Des exemplaires des publications de l’\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.<\/span>\n <\/a><\/div>\n\n\n\n
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Abr\u00e9viations<\/strong>:<\/em><\/h5>\n\n\n\n

CCR<\/strong>: carcinome \u00e0 cellules r\u00e9nales; HIF<\/strong>: facteur induit par l’hypoxie (hypoxia-inducible factor); VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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R\u00e9f\u00e9rences:<\/strong> <\/em><\/h5>\n\n\n\n
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  1. \n Information professionnelle de WELIREG\u00ae (Belzutifan),\u00a0www.swissmedicinfo.ch<\/a><\/mark><\/mark>, derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Ce m\u00e9dicament fait l’objet d’une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l\u2019information professionnelle de WELIREG\u00ae disponible sous www.swissmedicinfo.ch<\/a>.<\/em>

    Avant la prescription, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur     www.swissmedicinfo.ch<\/a>.<\/em><\/p>\n\n\n

    \n \n Information professionnelle de WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    WELIREG\u00ae – Un inhibiteur de HIF-2\u03b1<\/p>\n","protected":false},"author":202221,"featured_media":100993,"parent":99715,"menu_order":2,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[],"related_products":"","fact_sheet":null,"scientific_title":"","job_code":"","banner":100994,"primary_logo":null,"secondary_logo":null,"icon":null,"primary_tag":1524,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[],"tags":[1524,1523],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[957],"ga4_page_businessunit":[963],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[1206],"ga4_page_product":[],"ga4_page_region":[],"ga4_page_therapeuticarea":[],"tx-therapeutic-area":[627,931],"tx-product":[1522],"tx-pathology":[930,1525],"tx-content-type":[686],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-99729","product","type-product","status-publish","has-post-thumbnail","hentry","tag-welireg-2","tag-welireg"],"yoast_head":"\nM\u00e9canisme 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