{"id":99715,"date":"2025-08-22T06:51:24","date_gmt":"2025-08-22T06:51:24","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?post_type=product&p=99715"},"modified":"2026-03-06T09:16:32","modified_gmt":"2026-03-06T09:16:32","slug":"welireg","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/fr\/products\/welireg\/","title":{"rendered":"WELIREG\u00ae"},"content":{"rendered":"\n

Qu’est-ce que WELIREG\u00ae<\/h2>\n\n\n
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\n \"welireg\"\n\n <\/figure>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

WELIREG\u00ae (belzutifan) est un m\u00e9dicament qui agit comme inhibiteur du facteur 2-alpha induit par l’hypoxie (HIF-2\u03b1). Le HIF-2\u03b1 est un facteur de transcription important qui active, en cas de manque d’oxyg\u00e8ne, des g\u00e8nes favorisant la prolif\u00e9ration cellulaire, la formation de nouveaux vaisseaux sanguins et l’adaptation \u00e0 l’hypoxie. Normalement, le HIF-2\u03b1 est d\u00e9grad\u00e9 par la prot\u00e9ine VHL. En cas de d\u00e9ficit g\u00e9n\u00e9tique en VHL ou dans des conditions hypoxiques, le HIF-2\u03b1 reste stable et, par interaction avec le HIF-1\u03b2, active des g\u00e8nes qui favorisent la croissance tumorale. WELIREG\u00ae peut bloquer l’interaction du HIF-2\u03b1 avec le HIF-1\u03b2 , ce qui entra\u00eene une r\u00e9duction de la transcription et de l’expression des g\u00e8nes cibles de HIF-2\u03b1.1<\/sup><\/p>\n\n\n\n

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Indications<\/h2>\n\n\n\n

Envisagez WELIREG\u00ae, le premier et unique inhibiteur de HIF-2\u03b1*, comme une option de traitement syst\u00e9mique:<\/mark><\/strong><\/p>\n\n\n

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Dans le cadre de la VHL<\/strong><\/mark><\/h3>\n\n\n\n

Pour les patient(e)s atteint(e)s de certaines tumeurs associ\u00e9es \u00e0 VHL qui ne n\u00e9cessitent pas d\u2019intervention chirurgicale imm\u00e9diate.1<\/sup><\/strong><\/p>\n\n\n\n

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WELIREG\u00ae en monoth\u00e9rapie est indiqu\u00e9 pour le traitement des patients adultes atteints de la maladie de von Hippel-Lindau (VHL) qui n\u00e9cessitent une th\u00e8rapie pour des carcinomes \u00e0 cellules r\u00e9nales (CCR) associ\u00e9s \u00e0 VHL, des h\u00e9mangioblastomes du syst\u00e8me nerveux central (SNC) ou des tumeurs neuroendocrines pancr\u00e9atiques (TNEp), et qui ne n\u00e9cessitent pas d\u2019intervention chirurgicale imm\u00e9diate.1,a<\/sup>
Aucune donn\u00e9e n\u2019est disponible sur les tumeurs m\u00e9tastatiques associ\u00e9es \u00e0 VHL.1<\/sup><\/mark><\/p>\n\n\n\n

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\n \n WELIREG\u00ae dans le cadre de la VHL<\/span>\n <\/a><\/div>\n\n<\/div>\n\n\n
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Dans le cadre du CCR avanc\u00e9<\/mark><\/strong><\/h3>\n\n\n\n

Pour les patient(e)s atteint(e)s de certaines CCR ayant d\u00e9j\u00e0 re\u00e7u deux lignes de traitement ou plus, dans lesquelles un inhibiteur de PD-(L)1 et un inhibiteur de la tyrosine kinase VEGF ont \u00e9t\u00e9 utilis\u00e9s.1<\/sup><\/strong><\/p>\n\n\n\n

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\n \"icon\"\n\n <\/figure>\n\n\n\n
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WELIREG\u00ae en monoth\u00e9rapie est indiqu\u00e9 pour le traitement des patients adultes atteints de carcinome r\u00e9nal \u00e0 cellules claires (CCR) avanc\u00e9 non r\u00e9s\u00e9cable, qui a progress\u00e9 apr\u00e8s deux lignes de traitement ou plus, dont un inhibiteur du PD-(L)1 et un inhibiteur de tyrosine kinase VEGF.1<\/sup><\/mark><\/p>\n\n\n\n

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\n \n WELIREG\u00ae dans le cadre du CCR avanc\u00e9<\/span>\n <\/a><\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n
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Informations g\u00e9n\u00e9rales sur WELIREG\u00ae<\/h2>\n\n\n
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Mode d\u2019action<\/mark><\/strong><\/p>\n\n\n\n

D\u00e9couvrez comment agit WELIREG\u00ae.<\/mark><\/p>\n\n\n\n

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\n \n Vers le m\u00e9canisme d’action<\/span>\n <\/a><\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n
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Ressources<\/mark><\/strong><\/p>\n\n\n\n

Mat\u00e9riel pour les patient(e)s et informations suppl\u00e9mentaires sur WELIREG\u00ae.<\/mark><\/p>\n\n\n\n

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\n \n Vers les ressources<\/span>\n <\/a><\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n
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Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (belzutifan)<\/mark><\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n \n Vers l’information professionnelle abr\u00e9g\u00e9e\n<\/mark><\/span>\n <\/a><\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n
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* Le premier et unique inhibiteur de HIF-2\u03b1 approuv\u00e9 par Swissmedic.3<\/sup>
a. En raison de donn\u00e9es cliniques incompl\u00e8tes au moment de l\u2019examen de la demande, ces indications sont autoris\u00e9es pour une dur\u00e9e limit\u00e9e (art. 9a LPTh). L\u2019autorisation \u00e0 dur\u00e9e limit\u00e9e est imp\u00e9rativement li\u00e9e \u00e0 la satisfaction de charges en temps opportun. Une fois ces charges satisfaites, l\u2019autorisation \u00e0 dur\u00e9e limit\u00e9e pourra \u00eatre transform\u00e9e en autorisation ordinaire.1<\/sup><\/mark><\/em><\/p>\n\n\n\n

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\n \n Des exemplaires des publications de l’\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.<\/span>\n <\/a><\/div>\n\n\n\n
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Abr\u00e9viations<\/strong>:<\/mark><\/em><\/h5>\n\n\n\n

CCR<\/strong>: carcinome a cellules renales; HIF<\/strong>: facteur induit par l’hypoxie (hypoxia-inducible factor); SNC<\/strong>: syst\u00e8me nerveux central; TNEp<\/strong>: tumeurs neuroendocrines du pancr\u00e9as; VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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R\u00e9f\u00e9rences:<\/strong> <\/mark><\/em><\/h5>\n\n\n\n
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  1. \n Information professionnelle de WELIREG\u00ae (Belzutifan),\u00a0www.swissmedicinfo.ch<\/a><\/mark><\/mark>, derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n\n
  2. \n Narayan V, Jonasch E. Systemic therapy development in von Hippel\u2013Lindau disease: an outsized contribution from an orphan disease. Cancers (Basel). 2022; 14(21):5313.<\/em> <\/li>\n\n\n
  3. \n compendium.ch<\/a>, terme de recherche \u00abHIF-2alpha inhibiteur\u00bb, derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Ce m\u00e9dicament fait l’objet d’une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l\u2019information professionnelle de WELIREG\u00ae disponible sous www.swissmedicinfo.ch<\/a>.<\/em>

    Avant la prescription, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur     www.swissmedicinfo.ch<\/a>.<\/em><\/p>\n\n\n

    \n \n Information professionnelle de WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    Le premier et unique inhibiteur de HIF-2\u03b1 approuv\u00e9 pour les patient(e)s atteint(e)s de certaines tumeurs associ\u00e9es \u00e0 la maladie de VHL et de certains CCR non r\u00e9s\u00e9cables et avanc\u00e9s.<\/p>\n","protected":false},"author":202221,"featured_media":100975,"parent":0,"menu_order":0,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[{"label":"Information professionnelle 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