{"id":94862,"date":"2025-04-07T20:07:19","date_gmt":"2025-04-07T20:07:19","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?post_type=product&#038;p=94862"},"modified":"2025-11-27T13:29:09","modified_gmt":"2025-11-27T13:29:09","slug":"efficacite","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/fr\/products\/welireg\/ls004\/efficacite\/","title":{"rendered":"Efficacit\u00e9"},"content":{"rendered":"\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--f0ad37d268542124d5c974e1256bb8a1\">L&rsquo;efficacit\u00e9 et la s\u00e9curit\u00e9 de WELIREG\u00ae ont \u00e9t\u00e9 \u00e9tudi\u00e9es dans l&rsquo;\u00e9tude de phase 2 <strong>LITESPARK-004<\/strong>.<sup>1,2<\/sup><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--1d38fb2ca8d6dd4260903bfc765fcd03\" style=\"color:#123a8a\">Plan de l\u2019\u00e9tude<sup>2<\/sup><\/h2>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--03066107399a262822013437d3663a66\">\n                    <img loading=\"lazy\" decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99807\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-Study-Design.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"448\"\n                alt=\"Plan de l\u2019\u00e9tude\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--9ac9b559e933b1a1a77da16f33a890f3\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s l\u2019information professionnelle de WELIREG\u00ae<sup>1<\/sup> et Jonasch E, et al. , NEJM 2021.<sup>2<\/sup><br>a. La r\u00e9ponse conform\u00e9ment aux crit\u00e8res RECIST v1.1 \u00e9tait d\u00e9finie comme suit: \u2265 30% de diminution de la somme des diam\u00e8tres des l\u00e9sions cibles (la r\u00e9f\u00e9rence \u00e9tant la somme des diam\u00e8tres au d\u00e9but de l\u2019\u00e9tude).<sup>1,3<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--892c7830a44e6c95bca08778a1aa81a2\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99808\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-Study-Population.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"555\"\n        loading=\"lazy\"        alt=\"population\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--af0682de57a4b09b8bdf33e3089a7df5\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s l\u2019information professionnelle de WELIREG\u00ae<sup>1<\/sup> et Jonasch E, et al. , NEJM 2021.<sup>2<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-center mhh-mcn-v1-columns--35095cf8042dd71f2cd1e2639f8a13f1 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--09a7d9038cc1b6be2f768a9e5d26121e mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    \n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n<\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<h2 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--3aec2eb8ac3e0edca127a60e59753f36\" style=\"color:#123a8a\">R\u00e9sultats \u00e0 long terme de l&rsquo;\u00e9tude de phase 2 LITESPARK-004 avec un suivi m\u00e9dian de 49.9 (48.2 \u2013 58.1) mois<sup>4<\/sup><\/h2>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--1c74218cf8fa085460e19386057e0efc\">L\u2019\u00e9tude LITESPARK-004 a montr\u00e9 que WELIREG\u00ae avait un effet antitumoral durable sur les tumeurs associ\u00e9es \u00e0 la maladie de VHL, avec un suivi m\u00e9dian de plus de 4 ans.<sup>4<\/sup><\/p>\n\n\n\n<ul class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--4775a620f9a86c9b41bc3d673f926937 mhh-mcn-list mhh-mcn-v2-clist--unordered mhh-mcn-v2-clist--unordered-dot\" dir=\"ltr\" lang=\"en-US\" start=\"1\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    75% (n = 46) des patient(e)s ont subi 86 proc\u00e9dures de r\u00e9duction de la tumeur au cours des quatre ann\u00e9es pr\u00e9c\u00e9dant le d\u00e9but du traitement. 26% (n = 16) des patient(e)s ont subi 18 proc\u00e9dures de r\u00e9duction de tumeur apr\u00e8s le d\u00e9but du traitement parWELIREG\u00ae.<sup>4<\/sup>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    59% (n = 36) des patient(e)s \u00e9taient toujours sous traitement \u00e0 la date butoir.<sup>4<\/sup>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    Le profil de s\u00e9curit\u00e9 est rest\u00e9 largement inchang\u00e9.<sup>4<\/sup>    <\/li>\n\n<\/ul>\n\n\n<div class=\"mhh-mcn-v1-accordion mhh-mcn-v1-accordion--3fb5f6237c789aa2bbbda459bddc43e1 mhh-mcn-v1-accordion--multiple\" data-configuration=\"{&quot;variation&quot;:&quot;multiple&quot;,&quot;speed&quot;:0,&quot;hasFirstItemExpanded&quot;:false}\"    dir=\"ltr\"    lang=\"en-US\">\n    \n\n<section\n    id=\"accordion-6a04d4a1c07fe\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--c246af71efd6d7b136caf1810ffa58e3 mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a04d4a1c07fe-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a04d4a1c07fe-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--2629737cf0a29d0c69035f93fa352719\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-99719\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/Icon_Kidneys.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: CCR<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a04d4a1c07fe-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a04d4a1c07fe-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--65bb930333c623cfe6005aadb88cd352\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99805\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-RCC-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: CCR\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--59e6bfbaeb8e55993509b82e3884ad4a\"><mark class=\"has-inline-color has-black-color\"><em>Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/em><br><em>Dur\u00e9e m\u00e9diane de suivi entre la premi\u00e8re dose et la date butoir pour les donn\u00e9es (3 avril 2023) : 49.9 mois (intervalles: 48.2-58.1).<\/em><\/mark><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--c8feb1c34bb375e1c2db66291dc68a76\"><strong>WELIREG\u00ae a permis de diminuer la taille des tumeurs en cas de CCR associ\u00e9 \u00e0 la maladie de VHL<sup>4<\/sup><\/strong><\/h5>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--cdd69dbb6b004dea59eead12c80ef3f7\">Chez 41 patient(e) (67%), la taille des l\u00e9sions cibles a diminu\u00e9.<sup>4<\/sup><\/p>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--da27033d40fd83344786407d640d3421\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99803\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-RCC-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae a permis de diminuer la taille des tumeurs en cas de CCR associ\u00e9 \u00e0 la maladie de VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--dfb6744ac1b1e6a3a782303e1a23e6a2\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--ed8516ce55be6e018e9022f8460bb66c\"><strong>Dur\u00e9e du traitement par WELIREG\u00ae des l\u00e9sions cibles du CCR associ\u00e9 \u00e0 VHL, meilleur taux de r\u00e9ponse global et statut de progression de la maladie<sup>4<\/sup><\/strong><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--8763a12117adb6cb1feb6dfe35dbb6a8\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99806\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-RCC-Treatment-Duration.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"580\"\n        loading=\"lazy\"        alt=\"Dur\u00e9e du traitement par WELIREG\u00ae des l\u00e9sions cibles du CCR associ\u00e9 \u00e0 VHL, meilleur taux de r\u00e9ponse global et statut de progression de la maladie\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--dfb6744ac1b1e6a3a782303e1a23e6a2\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--2760ae50d12b072d6ffd4591f6b87a69\"><strong>\u00c9valuation Kaplan-Meier de DOR et PFS dans le CCR associ\u00e9 \u00e0 la maladie de VHL<\/strong><sup><strong>4,a<\/strong><\/sup><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--5caf2a0d336c6ad5a75aec2ba791a8b1\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99804\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-RCC-DOR-PFS.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"387\"\n        loading=\"lazy\"        alt=\"\u00c9valuation Kaplan-Meier de DOR et PFS dans le CCR associ\u00e9 \u00e0 la maladie de VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--666def08b2a779ef0500e8966093b956\"><mark class=\"has-inline-color has-black-color\"><em>Graphiques adapt\u00e9s d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/em><br><em>a. selon RECIST v1.1 par l\u2019IRC.<\/em><br><em>+ indique que la r\u00e9ponse est toujours en cours.<\/em><\/mark><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a04d4a1c2c92\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--a56cc402c312887eb234e71b99b0f725 mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a04d4a1c2c92-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a04d4a1c2c92-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--1f450dd60c522ac2485d437f9e42c0ee\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-99720\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/Icon_Brain.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: h\u00e9mangioblastomes du SNC<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a04d4a1c2c92-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a04d4a1c2c92-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--3b2b624d6533086d47846d32724e0dc6\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99799\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-CNS-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: h\u00e9mangioblastomes du SNC\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--21b38110269b9c2832bba357f66ed858\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Donn\u00e9es insuffisantes pour \u00e9valuer la r\u00e9ponse selon RECIST v1.1.<br>+ indique que la r\u00e9ponse est toujours en cours.<br>Dur\u00e9e m\u00e9diane de suivi entre la premi\u00e8re dose et la date butoir pour les donn\u00e9es (3 avril 2023) : 49.9 mois (intervalles: 48.2-58.1).<\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--51cfb314b26bb8f437369aba5b8a44bc\"><strong>WELIREG\u00ae a permis de diminuer la taille des h\u00e9mangioblastomes du SNC associ\u00e9s \u00e0 la maladie de VHL<sup>4<\/sup><\/strong><sup>,a<\/sup><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--7479a344b891761851dcfccc2b770f1f\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99798\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-CNS-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae a permis de diminuer la taille des h\u00e9mangioblastomes du SNC associ\u00e9s \u00e0 la maladie de VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--627d5b5c26465f261af9637f0f455aaf\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Des donn\u00e9es \u00e9valuables apr\u00e8s le d\u00e9but de l\u2019\u00e9tude avec une maladie mesurable \u00e9taient disponibles pour 30 des 50 patient(e)s; 4 patient(e)s ont obtenu une CR, dont 3 patient(e)s qui ne pr\u00e9sentaient qu\u2019une maladie non mesurable au d\u00e9but de l\u2019\u00e9tude, et 3 patient(e)s ont eu une PD, dont 2 qui ne pr\u00e9sentaient qu\u2019une maladie non mesurable au d\u00e9but de l\u2019\u00e9tude (non repr\u00e9sent\u00e9(e)s dans le diagramme en cascade). Date butoir: 3 avril 2023.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a04d4a1c449f\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--341f1522dc32d02726e7469ec366ef24 mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a04d4a1c449f-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a04d4a1c449f-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--0a806895d7d54b21b3638473278f5ece\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-99721\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/Icon_Pancreas.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: TNEp<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a04d4a1c449f-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a04d4a1c449f-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--4c6a31f1380bf50a7de8e1fc49ece2e4\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99802\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-pNET-ORR.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"330\"\n        loading=\"lazy\"        alt=\"R\u00e9sultats de l\u2019analyse de suivi \u00e9tendue \u00e0 49.9 (48.2 \u2013 58.1) mois: TNEp\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-link-color has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--86139f9b3b286710c71a8bca21e981a1\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><br>a. Donn\u00e9es insuffisantes pour \u00e9valuer la r\u00e9ponse selon RECIST v1.1.<br>b. Les donn\u00e9es concernent toutes les l\u00e9sions pancr\u00e9atiques (n = 61), y compris les l\u00e9sions TNEp et non TNEp.<br>+ indique que la r\u00e9ponse est toujours en cours.<br>Dur\u00e9e m\u00e9diane de suivi entre la premi\u00e8re dose et la date butoir pour les donn\u00e9es (3 avril 2023) : 49.9 mois (intervalles: 48.2-58.1).<\/mark><\/em><\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--78c4b86688fc509f0a2989b0c2369e94\"><strong>WELIREG\u00ae a permis de r\u00e9duire la taille des TNEp associ\u00e9es \u00e0 la maladie de VHL<sup>4<\/sup><\/strong><\/h5>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--3e01eb292ba7ca17af61ec952568213c\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99801\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-pNET-Change-Target-Lesions.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"629\"\n        loading=\"lazy\"        alt=\"WELIREG\u00ae a permis de r\u00e9duire la taille des TNEp associ\u00e9es \u00e0 la maladie de VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--dfb6744ac1b1e6a3a782303e1a23e6a2\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n<section\n    id=\"accordion-6a04d4a1c528d\"\n    class=\"mhh-mcn-v1-accordion-molecule mhh-mcn-v1-accordion-molecule--df40bb2089e972860d3f9027fc4d1f1e mhh-mcn-v1-accordion-molecule--closed\"\n            >\n    <h4\n        id=\"accordion-6a04d4a1c528d-header\"\n        class=\"mhh-mcn-v1-accordion-molecule-header\"\n    >\n        <button\n            class=\"mhh-mcn-v1-accordion-molecule-header__heading\"\n            aria-expanded=\"false\"\n            aria-controls=\"accordion-6a04d4a1c528d-content\"\n        >\n                            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon\" aria-hidden=\"true\">\n                    <figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--5c37ae7aca9802e6bd10b8d5ff7c75ed\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--thumbnail wp-image-99832\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/Icon_Operation.png?w=150&#038;h=150&#038;crop=1&#038;quality=80&#038;lossy=1\"\n        width=\"150\"\n        height=\"150\"\n        loading=\"lazy\"        alt=\"\"\n            \/>\n            <\/figure>\n                <\/span>\n                        <span class=\"mhh-mcn-v1-accordion-molecule-header__title\">\n                Op\u00e9rations dues \u00e0 la maladie de VHL<sup>4<\/sup>            <\/span>\n            <span class=\"mhh-mcn-v1-accordion-molecule-header__icon-dropdown\" aria-hidden=\"true\">\n                \n<svg width=\"1em\" height=\"1em\" class=\"mh-icon mh-icon--kind-generic mh-icon--name-dropdown-arrow mh-icon--dropdown-arrow\" role=\"img\" aria-hidden=\"true\">\n    \n    \n    <use xlink:href=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/themes\/cex-wpvip-mhh-mconnect-theme-new-3.0\/modules\/icons\/resources\/icons\/svg\/generic\/dropdown-arrow.svg#dropdown-arrow\"><\/use>\n<\/svg>\n            <\/span>\n        <\/button>\n    <\/h4>\n    <div\n        id=\"accordion-6a04d4a1c528d-content\"\n        class=\"mhh-mcn-v1-accordion-molecule-content\"\n        role=\"region\"\n        aria-labelledby=\"accordion-6a04d4a1c528d-header\"\n    >\n        <div class=\"mhh-mcn-v1-accordion-molecule-content__body\">\n            \n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--b9490acac8d18d16fc6d0d4ceafb7bd6\">WELIREG\u00ae a permis de diminuer le nombre d\u2019op\u00e9rations li\u00e9es \u00e0 la maladie de VHL.<sup>4<\/sup><\/p>\n\n\n<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--ff7e36b8bff3e2e9c75a324110e5f583\">\n                    <img decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-99800\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/04\/F-WELIREG-LS004-Operations.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"501\"\n        loading=\"lazy\"        alt=\"Op\u00e9rations dues \u00e0 la maladie de VHL\"\n            \/>\n            <\/figure>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color has-object-object-font-size   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--dfb6744ac1b1e6a3a782303e1a23e6a2\"><em><mark class=\"has-inline-color has-black-color\">Adapt\u00e9 d\u2019apr\u00e8s Srinivasan R., et al., AACR 2024.<sup>4<\/sup><\/mark><\/em><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-center mhh-mcn-v1-columns--35095cf8042dd71f2cd1e2639f8a13f1 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--09a7d9038cc1b6be2f768a9e5d26121e mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-6 mhh-mcn-column--l-6\">\n    \n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n<\/div>\n\n\n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--9d868bac18358936d21b523ac257cec5 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-3 mhh-mcn-column--l-3\">\n    <\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--c81e54e7e9bcfc71911296339f7c3b93 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--c74e17b481f26f0bf3bbddad36bbe688 mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--55df8fe8b3ce67735f81ed8ffbfe4d6c mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--2dce915841690a37740f97f042d6454a mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n<div class=\"mhh-mcn-columns mhh-mcn-columns--vertical-alignment-top mhh-mcn-v1-columns--cbd4c2cedf0711bb9a91b8bbf71fe020 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--34f82833b7dad5c608ae41bed6e8319b mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h3 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-text-color has-link-color wp-elements-65d2c7774c7ffc5e08031011e7cb2055  mhh-mcn-v1-heading mhh-mcn-v1-heading--2c8e187cf0ab88353788bb1fc1ef85e8\" style=\"color:#123a8a\"><strong>Les r\u00e9sultats \u00e0 long terme de l&rsquo;\u00e9tude <span class=\"no-text-breaking\">LITESPARK-004<\/span> (analyse de suivi \u00e0 49.9 (48.2 \u2013 58.1) mois) continuent de soutenir l&rsquo;efficacit\u00e9 de WELIREG\u00ae pour le CCR associ\u00e9 \u00e0 la maladie de VHL, les h\u00e9mangioblastomes du SNC et les TNEp.<sup>4<\/sup><\/strong><\/h3>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--1df10307e1925828dedd9c606ec15f4d\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--875692e5cbece2659e5d362f80170231\" href=\"mailto:%20dpoc.switzerland@msd.com\" target=\"_self\" aria-label=\"Des exemplaires des publications de l&#039;\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.\">\n                    <span class=\"mhh-mcn-v1-link__label\">Des exemplaires des publications de l&rsquo;\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.<\/span>\n                <\/a><\/div>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--81430e5d7fdd66c90c6c891c47982ba5 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--e87bb88a34fe11063a3b07262c46593d mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--fa395fb17d9535d2044ae0ed37b63b3f\"><em><mark class=\"has-inline-color has-black-color\"><strong>Abr\u00e9viations<\/strong>:<\/mark><\/em><\/h5>\n\n\n\n<p class=\"has-gray-700-color has-text-color has-object-object-font-size has-border-color has-has-red-border-color-border-color has-black-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--93f337bd0fa70895f914b3b5ac3bbfc2\"><em><mark class=\"has-inline-color has-black-color\"><strong>CCR<\/strong>: carcinome \u00e0 cellules r\u00e9nales; <strong>CR<\/strong>: r\u00e9ponse compl\u00e8te (complete response); <strong>DOR<\/strong>: dur\u00e9e de r\u00e9ponse (duration of response); <strong>ECOG PS<\/strong>: Eastern Cooperative Oncology Group performance status; <strong>IRC<\/strong>: comit\u00e9 d\u2019\u00e9valuation ind\u00e9pendant (independent review committee); <strong>ORR<\/strong>: taux de r\u00e9ponse globale (overall response rate); <strong>PD<\/strong>: maladie progressive (progressive disease); <strong>PR<\/strong>: r\u00e9ponse partielle (partial response); <strong>RECIST v1.1<\/strong>: Response Evaluation Criteria In Solid Tumors v1.1; <strong>SD<\/strong>: maladie stable (stable disease); <strong>SNC<\/strong>: syst\u00e8me nerveux central; <strong>TNEp<\/strong>: tumeurs neuroendocrines du pancr\u00e9as; <strong>TTR<\/strong>: d\u00e9lai de r\u00e9ponse (time to response); <strong>TTS<\/strong>: d\u00e9lai jusqu\u2019\u00e0 l\u2019op\u00e9ration (time to surgery); <strong>VHL<\/strong>: Von-Hippel-Lindau.<\/mark><\/em><\/p>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n<div class=\"mhh-mcn-columns mhh-mcn-v1-columns--f9911ca6b7b3fe255bd4e6032b568367 mhh-mcn-v1-columns mhh-mcn-columns--gutter-m\">\n    <div class=\"mhh-mcn-columns-inner\">\n        \n<div class=\"mhh-mcn-v1-column mhh-mcn-v1-column--76339cf7cd9a3e0fb144dd7a93d4c07c mhh-mcn-column mhh-mcn-column--12 mhh-mcn-column--m-12 mhh-mcn-column--l-12\">\n    \n\n<h5 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--39305477333db91b193ce9169c86965c\"><em><mark class=\"has-inline-color has-black-color\"><strong>R\u00e9f\u00e9rences:<\/strong> <\/mark><\/em><\/h5>\n\n\n\n<ol class=\"mhh-mcn-v2-clist mhh-mcn-v2-clist--81b36b17c96a905498bfb37c353c6424 mhh-mcn-list mhh-mcn-v2-clist--ordered mhh-mcn-v2-clist--ordered-decimal\" dir=\"ltr\" lang=\"en-US\" start=\"1\">\n    \n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Information professionnelle de WELIREG\u00ae (Belzutifan)<mark class=\"has-inline-color has-gray-700-color\"><mark class=\"has-inline-color has-gray-700-color\">,\u00a0<a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo.ch<\/a><\/mark><\/mark>, derni\u00e8re consultation le 07.03.2025.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Jonasch E, et al. Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. N Engl J Med. 2021;385:2036\u2009\u2013\u20092046. DOI: 10.1056\/NEJMoa2103425.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Eisenhauer EA, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228 \u2013 247.<\/em>    <\/li>\n\n\n<li class=\"mhh-mcn-list-item mhh-mcn-v2-list-item\">\n    <em>Srinivasan R, et al. Belzutifan, a Hypoxia-Inducible Factor-2\u03b1 Inhibitor, for von Hippel-Lindau Disease\u2013Associated Neoplasms: Long-Term Results of the Phase 2 LITESPARK-004 Study. Presented at the American Association for Cancer Research (AACR) Annual Meeting; San Diego, California; April 5 \u2013 10, 2024.<\/em>    <\/li>\n\n<\/ol>\n\n<\/div>\n\n    <\/div>\n\n    <\/div>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--371b4589b234ac34456a76f58b7ad0a0\"><mark class=\"has-inline-color has-black-color\">\u25bc <em>Ce m\u00e9dicament fait l&rsquo;objet d&rsquo;une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l\u2019information professionnelle de WELIREG\u00ae disponible sous <a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo.ch<\/a>.<\/em><br><br><em>Avant la prescription, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur\u00a0<a href=\"https:\/\/www.swissmedicinfo.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo.ch<\/a>.<\/em><\/mark><\/p>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--a4b2e6dd9bc1e5063a3cb4413c58fb90\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--9e8104a6f5eec9849dd3d04c4bebc2f7 mhh-mcn-v1-link--is-variation mhh-mcn-v1-link--button-custom\" href=\"https:\/\/www.swissmedicinfo-pro.ch\/showText.aspx?textType=FI&#038;lang=FR&#038;authNr=68531&#038;supportMultipleResults=1\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Information professionnelle de WELIREG\u00ae\">\n                    <span class=\"mhh-mcn-v1-link__label\">Information professionnelle de WELIREG\u00ae<\/span>\n                <\/a><\/div>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--3792025ea97d0a7c9ce392b8bb3d3780\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--fab7de5fa295e2a7924fb0c35177fc95 mhh-mcn-v1-link--is-variation mhh-mcn-v1-link--button-custom\" href=\"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/welireg\/\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae\">\n                    <span class=\"mhh-mcn-v1-link__label\">Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae<\/span>\n                <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sous WELIREG\u00ae, une r\u00e9ponse objective pour les trois tumeurs associ\u00e9es \u00e0 la maladie de VHL a \u00e9t\u00e9 observ\u00e9e.<\/p>\n","protected":false},"author":202221,"featured_media":99842,"parent":99751,"menu_order":4,"template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":true,"isSticky":true},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"product_resource":[],"related_products":"","fact_sheet":null,"scientific_title":"","job_code":"","banner":99811,"primary_logo":null,"secondary_logo":null,"icon":null,"primary_tag":1524,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[693,597],"tags":[1524,1523],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[957],"ga4_page_businessunit":[963],"ga4_page_campaign":[],"ga4_page_content_purpose":[992],"ga4_page_customer_journey_stage":[1012],"ga4_page_customer_specialty":[1052],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[1206],"ga4_page_product":[1216],"ga4_page_region":[1462],"ga4_page_therapeuticarea":[1497],"tx-therapeutic-area":[627,931],"tx-product":[1522],"tx-pathology":[1525],"tx-content-type":[686,715],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-94862","product","type-product","status-publish","has-post-thumbnail","hentry","category-indications","category-information-produit","tag-welireg-2","tag-welireg"],"yoast_head":"<!-- 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