{"id":100887,"date":"2025-08-22T06:41:19","date_gmt":"2025-08-22T06:41:19","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?post_type=product&p=100887"},"modified":"2025-08-22T06:42:47","modified_gmt":"2025-08-22T06:42:47","slug":"ls005","status":"publish","type":"product","link":"https:\/\/www.mymsd.ch\/fr\/products\/welireg\/ls005\/","title":{"rendered":"WELIREG\u00ae pour l\u2019aRCC"},"content":{"rendered":"\n

Le prix Nobel de m\u00e9decine 2019 a r\u00e9compens\u00e9 la d\u00e9couverte d’un m\u00e9canisme physiologique central par lequel les cellules d\u00e9tectent la teneur en oxyg\u00e8ne de leur environnement et y r\u00e9agissent. Ce syst\u00e8me de r\u00e9gulation comprend les prot\u00e9ines induites par l’hypoxie (HIF), la prot\u00e9ine Von Hippel-Lindau (VHL) et l’\u00e9rythropo\u00ef\u00e9tine (EPO).2<\/sup> Ces d\u00e9couvertes fondamentales sont d\u00e9terminantes pour le principe actif de WELIREG\u00ae.1<\/sup><\/p>\n\n\n

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WELIREG\u00ae peut permettre de nouvelles approches th\u00e9rapeutiques chez certain(e)s patient(e)s atteint(e)s d\u2019un carcinome r\u00e9nal \u00e0 cellules claires avanc\u00e9 et non op\u00e9rable.1<\/sup><\/strong><\/p>\n\n<\/blockquote>\n\n\n\n

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\n \n Vers le mode d\u2019action<\/span>\n <\/a><\/div>\n\n\n
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WELIREG\u00ae en monoth\u00e9rapie est indiqu\u00e9 pour le traitement des patients adultes atteints de carcinome r\u00e9nal \u00e0 cellules claires (CCR) avanc\u00e9 non r\u00e9s\u00e9cable, qui a progress\u00e9 apr\u00e8s deux lignes de traitement ou plus, dont un inhibiteur du PD-(L)1 et un inhibiteur de tyrosine kinase VEGF.1<\/sup><\/mark><\/p>\n\n <\/div>\n<\/section>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

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* Le premier et unique inhibiteur de HIF-2\u03b1 approuv\u00e9 par Swissmedic.3<\/sup><\/mark><\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

\n \n Vers l\u2019efficacit\u00e9<\/span>\n <\/a><\/div>\n\n\n\n
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\n \n Des exemplaires des publications de l’\u00e9tude peuvent \u00eatre demand\u00e9s \u00e0 dpoc.switzerland@msd.com si n\u00e9cessaire.<\/span>\n <\/a><\/div>\n\n\n\n
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Abr\u00e9viations<\/strong>:<\/mark><\/em><\/h6>\n\n\n\n

CCR<\/strong>: carcinome a cellules renales; EPO<\/strong>: \u00e9rythropo\u00ef\u00e9tine; HIF<\/strong>: facteur induit par l’hypoxie (hypoxia-inducible factor); VHL<\/strong>: Von-Hippel-Lindau.<\/em><\/p>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n

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R\u00e9f\u00e9rences:<\/strong> <\/mark><\/em><\/h6>\n\n\n\n
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  1. \n Information professionnelle de WELIREG\u00ae (belzutifan),\u00a0www.swissmedicinfo.ch<\/a><\/mark><\/mark>, derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n\n
  2. \n The Nobel Prize. Nobel Prize in Physiology or Medicine 2019: Scientific Background. How cells sense and adapt to oxygen availability. Available from: URL: https:\/\/www.nobelprize.org\/prizes\/medicine\/2019\/advanced-information\/<\/a>; derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n\n
  3. \n compendium.ch<\/a>, terme de recherche \u00abHIF-2alpha inhibiteur\u00bb, derni\u00e8re consultation le 22.08.2025.<\/em> <\/li>\n\n<\/ol>\n\n<\/div>\n\n <\/div>\n\n <\/div>\n\n\n\n

    \u25bc Ce m\u00e9dicament fait l’objet d’une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l\u2019information professionnelle de WELIREG\u00ae disponible sous www.swissmedicinfo.ch<\/a>.<\/mark><\/em>

    Avant la prescription, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur     www.swissmedicinfo.ch<\/a>.<\/mark><\/em><\/p>\n\n\n

    \n \n Information professionnelle de WELIREG\u00ae<\/span>\n <\/a><\/div>\n\n\n
    \n \n Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae<\/span>\n <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

    Le prix Nobel de m\u00e9decine 2019 a r\u00e9compens\u00e9 la d\u00e9couverte d’un m\u00e9canisme physiologique central par lequel les cellules d\u00e9tectent la 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