{"id":53806,"date":"2022-04-22T08:46:59","date_gmt":"2022-04-22T08:46:59","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?p=53806"},"modified":"2025-11-23T19:04:02","modified_gmt":"2025-11-23T19:04:02","slug":"update-shcs","status":"publish","type":"post","link":"https:\/\/www.mymsd.ch\/fr\/hiv\/update-shcs\/","title":{"rendered":"Nouvelles informations concernant l\u2019\u00e9tude suisse de cohorte VIH"},"content":{"rendered":"\n

L’\u00e9tude suisse de cohorte VIH (SHCS), nationale et multicentrique, inclut constamment des personnes s\u00e9ropositives au VIH depuis 1988, afin d’observer l’\u00e9pid\u00e9mie de VIH en Suisse. Apr\u00e8s 30 ans de suivi, l’\u00e9volution de la cohorte des personnes vivant avec le VIH en Suisse et la disponibilit\u00e9 de nouveaux m\u00e9dicaments ouvrent de nouveaux domaines de recherche. \u00c0 la fin 2019, 9816 participants (\u00e2ge moyen de 52 ans) avaient \u00e9t\u00e9 suivis. Une biobanque de 1,7 million d’\u00e9chantillons de sang collect\u00e9s sur plus de 30 ans permet d’effectuer des analyses de laboratoire modernes.<\/p>\n\n\n\n

R\u00e9orientation de l’\u00e9tude<\/strong><\/p>\n\n\n\n

Au cours des dix derni\u00e8res ann\u00e9es, le traitement des personnes atteintes du VIH a \u00e9t\u00e9 consid\u00e9rablement am\u00e9lior\u00e9 gr\u00e2ce \u00e0 de nouvelles th\u00e9rapies, plus simples et plus efficaces. Les principales caract\u00e9ristiques des patients concern\u00e9s ont aussi fortement chang\u00e9. L’\u00e9tude SHCS porte d\u00e9sormais sur une population vieillissante, essentiellement en raison de l’allongement important de l’esp\u00e9rance de vie des personnes s\u00e9ropositives en Suisse. Elle a \u00e9galement observ\u00e9 un changement de comportement de cette population. \u00c0 l’heure actuelle, une plus grande partie des participants \u00e0 l’\u00e9tude SHCS ont des rapports sexuels sans pr\u00e9servatif. L’\u00e9tude SHCS se concentre sur les th\u00e8mes de recherche suivants: com\u00e9dication et comorbidit\u00e9s, effets des nouvelles strat\u00e9gies th\u00e9rapeutiques, maladies sexuellement transmissibles, g\u00e9nomique de l’h\u00f4te et m\u00e9decine de pr\u00e9cision, transmission du VIH, d\u00e9veloppement d’anticorps neutralisants \u00e0 large spectre (bNabs), gu\u00e9rison (cure) du VIH, et analyse en termes d’\u00e9conomie de la sant\u00e9 et rentabilit\u00e9 du traitement du VIH.<\/p>\n\n\n\n

Quels sont les changements constat\u00e9s chez les participants \u00e0 l’\u00e9tude SHCS?<\/strong><\/p>\n\n\n\n

L’\u00e9tude SHCS couvre 71% de l’ensemble des patients sous TAR en Suisse. En 2019, moins d’un mois s’\u00e9coulait entre le diagnostic de VIH et l’instauration du TAR. \u00c0 la fin 2019, 9462 (96,8%) des patients avaient re\u00e7u un traitement et 9501 (97,2%) pr\u00e9sentaient une charge virale (CV) inf\u00e9rieure \u00e0 400 copies\/ml. Depuis le d\u00e9but de la cohorte, les caract\u00e9ristiques des patients ont \u00e9galement fortement \u00e9volu\u00e9: l’\u00e2ge m\u00e9dian a augment\u00e9 en raison de la hausse du nombre de patients virologiquement contr\u00f4l\u00e9s, passant de 45 [33-57] ans en 2009 \u00e0 52 [37-67] ans en 2019. En parall\u00e8le, l’indice de masse corporelle (IMC) m\u00e9dian des participants est pass\u00e9 de 23,4 [21,1 \u2013 25,9] en 2009 \u00e0 24,8 [22,3 \u2013 27,8] en 2019. Ces derniers temps, le type de transmission de l’infection a \u00e9galement chang\u00e9: par exemple, l’importance des rapports homosexuels (40.9% en 2009 \u00e0 46,8% en 2019) et de l’UDI comme voies de transmission possibles a diminu\u00e9 (15.9% en 2009 \u00e0 9,9% en 2019).<\/p>\n\n\n\n

Sur quoi portait l’\u00e9tude SHCS et quels en sont les Key Findings?<\/strong><\/p>\n\n\n\n

Les participants \u00e0 l’\u00e9tude SHCS se pr\u00e9sentent deux fois par an pour un examen, selon une proc\u00e9dure standardis\u00e9e. L’\u00e9tude SHCS comporte toutefois aussi plusieurs sous-groupes d’\u00e9tude, notamment \u00abMetabolics and Ageing (M\u00feA) and Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO)\u00bb, \u00abSHCS drug resistance study\u00bb et \u00abThe Swiss Mother and Child Cohort Study\u00bb.<\/p>\n\n\n\n

L’\u00e9tude SHCS comprend divers r\u00e9sultats d’\u00e9tudes. Depuis le d\u00e9but de la cohorte \u00e0 la fin des ann\u00e9es 1980, plus de 600 \u00e9tudes originales ont \u00e9t\u00e9 publi\u00e9es, notamment sur des th\u00e8mes contribuant \u00e0 une meilleure compr\u00e9hension de l’\u00e9pid\u00e9mie de VIH en Suisse, \u00e0 des fins de documentation et de meilleure compr\u00e9hension du sch\u00e9ma de TAR, afin d’analyser la pr\u00e9valence de la r\u00e9sistance aux m\u00e9dicaments contre le VIH ou de d\u00e9crire les complications m\u00e9taboliques.<\/p>\n\n\n\n

Quels sont les points forts et faibles de l’\u00e9tude SHCS?<\/strong><\/p>\n\n\n\n

Les principaux points forts de l’\u00e9tude SHCS r\u00e9sident dans la qualit\u00e9 des donn\u00e9es, syst\u00e9matiquement collect\u00e9es depuis 30 ans, avec le recueil de donn\u00e9es longitudinales exceptionnelles issues d’\u00e9chantillons de sang. 71% des patients sous TAR sont inclus dans l’\u00e9tude SHCS.<\/p>\n\n\n\n

L’un de ses points faibles r\u00e9side dans le fait que la cohorte ne comporte pas de t\u00e9moins s\u00e9ron\u00e9gatifs et que les minorit\u00e9s ethniques y sont sous-repr\u00e9sent\u00e9es.<\/p>\n\n\n

\n \n Vous pouvez lire l’int\u00e9gralit\u00e9 de l’article ici<\/strong><\/span>\n <\/a><\/div>\n\n\n\n
Abr\u00e9viations:<\/strong><\/h5>\n\n\n\n

Abr\u00e9viations: <\/strong>TAR: traitement antir\u00e9troviral; UDI: usage de drogues par voie intraveineuse; SHCS: Swiss HIV Cohort Study (\u00e9tude suisse de\u00a0cohorte HIV).<\/p>\n\n\n\n

R\u00e9f\u00e9rence:<\/strong><\/h5>\n\n\n\n
    \n \n
  1. \n Scherrer AU, Traytel A, Braun DL, Calmy A, Battegay M, Cavassini M, Furrer H, Schmid P, Bernasconi E, Stoeckle M, Kahlert C, Trkola A, Kouyos RD, Tarr P, Marzolini C, Wandeler G, Fellay J, Bucher H, Yerly S, Suter F, Hirsch H, Huber M, Dollenmaier G, Perreau M, Martinetti G, Rauch A, G\u00fcnthard HF; Swiss HIV Cohort Study (SHCS). Cohort Profile Update: The Swiss HIV Cohort Study (SHCS). Int\u00a0J\u00a0Epidemiol. 2022 Feb 18;51(1):33-34j.\u00a0doi: 10.1093\/ije\/dyab141. <\/li>\n\n<\/ol>\n\n\n\n

    Vous pouvez demander une copie de l’\u00e9tude \u00e0 l’adresse dpoc.switzerland@msd.com<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Ces nouvelles informations concernent la composition actuelle et modifi\u00e9e de la cohorte, les principaux r\u00e9sultats de l’ann\u00e9e derni\u00e8re et la nouvelle orientation scientifique de l’\u00e9tude suisse de cohorte VIH (SHCS).<\/p>\n","protected":false},"author":1839,"featured_media":53807,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":false,"isSticky":false},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"icon":null,"job_code":"","hide_featured_image":false,"primary_tag":733,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[806,830],"tags":[733,810,814],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[959],"ga4_page_businessunit":[965],"ga4_page_campaign":[],"ga4_page_content_purpose":[],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[1206],"ga4_page_product":[],"ga4_page_region":[],"ga4_page_therapeuticarea":[],"tx-therapeutic-area":[],"tx-product":[604],"tx-pathology":[],"tx-content-type":[795],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-53806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hiv","category-hiv-nl3","tag-delstrigo-pifeltro","tag-hiv","tag-nl3"],"yoast_head":"\nNouvelles 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