{"id":99413,"date":"2025-08-22T06:38:08","date_gmt":"2025-08-22T06:38:08","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?page_id=99413"},"modified":"2026-02-17T09:15:04","modified_gmt":"2026-02-17T09:15:04","slug":"welireg","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/welireg\/","title":{"rendered":"Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan)"},"content":{"rendered":"<figure class=\"mhh-mcn-v1-image mhh-mcn-v1-image--align-full mhh-mcn-v1-image--b306995221468c5ffb04299b0e2241b8 mhh-mcn-v1-image--align-items-center\">\n                    <img loading=\"lazy\" decoding=\"async\"\n        class=\"mhh-mcn-image mhh-mcn-image--full wp-image-101017\"\n        src=\"https:\/\/www.mymsd.ch\/fr\/wp-content\/uploads\/sites\/30\/2025\/08\/F-WELIREG-Banner-SPI-202508.jpg?quality=80&#038;lossy=1\"\n        width=\"1024\"\n        height=\"256\"\n                alt=\"\"\n            \/>\n            <\/figure>\n\n\n\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--2b22b21a4029c7de5cb203870caea9f6\"><mark style=\"color:#123a8a\" class=\"has-inline-color\">Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--474aef2ac962961f52cc8fa9beea6520\"><em>\u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle de WELIREG\u00ae disponible sous <a href=\"https:\/\/swissmedicinfo-pro.ch\/showText.aspx?textType=FI&amp;lang=FR&amp;authNr=68531&amp;supportMultipleResults=1\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">www.swissmedicinfo-pro.ch<\/a>.<\/em><\/p>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--dcefb4f67e6c30f76f66d2ef2bb5b380\"><strong>WELIREG\u00ae<\/strong>: <strong>C<\/strong>: Belzutifan; <strong>I<\/strong>: En monoth\u00e9rapie pour le traitement des patients adultes atteints de carcinome r\u00e9nal \u00e0 cellules claires (CCR) avanc\u00e9 non r\u00e9s\u00e9cable, qui a progress\u00e9 apr\u00e8s deux lignes de traitement ou plus, dont un inhibiteur du PD-(L)1 et un inhibiteur de tyrosine kinase VEGF; <strong>Po<\/strong>: 120 mg (trois comprim\u00e9s de 40 mg), orale, une fois par jour, jusqu\u2019\u00e0 la progression de la maladie ou l\u2019apparition d\u2019une toxicit\u00e9 inacceptable, ajuster la dose en cas d&rsquo;effets ind\u00e9sirables, ajuster la dose en cas de troubles s\u00e9v\u00e8res de la fonction r\u00e9nale. <strong>Pour d&rsquo;autres indications et les dosages correspondants pour les adultes, veuillez vous r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle<\/strong>. <strong>CI<\/strong>: Hypersensibilit\u00e9 au principe actif\/excipients; <strong>Pr<\/strong>: An\u00e9mie li\u00e9e \u00e0 un d\u00e9ficit en \u00e9rythropo\u00ef\u00e9tine: surveiller r\u00e9guli\u00e8rement et en cas d&rsquo;an\u00e9mie, ajuster la posologie. Hypoxie: peut provoquer une hypoxie s\u00e9v\u00e8re, surveiller la saturation en oxyg\u00e8ne, arr\u00eater de fumer recommand\u00e9, r\u00e9duire la dose ou arr\u00eater. Toxicit\u00e9 embryof\u0153tale: peut \u00eatre nocif pour le f\u0153tus chez l\u2019humain ou entra\u00eener une perte f\u0153tale, utiliser une m\u00e9thode de contraception non hormonale hautement efficace. Peut alt\u00e9rer la fertilit\u00e9; <strong>IA<\/strong>: L&rsquo;administration concomitante avec des substrats du CYP3A4 (y compris des contraceptifs hormonaux) peut diminuer leur efficacit\u00e9. L&rsquo;administration concomitante avec des inhibiteurs de l&rsquo;UGT2B17 ou du CYP2C19 augmente l&rsquo;exposition plasmatique au belzutifan, ce qui peut augmenter des effets ind\u00e9sirables; <strong>G\/A<\/strong>: Non recommand\u00e9; avant le traitement par belzutifan, v\u00e9rifier l\u2019absence de grossesse chez les femmes en \u00e2ge de procr\u00e9er; utiliser contraception non hormonale hautement efficace chez les femmes en \u00e2ge de procr\u00e9er et chez les hommes ayant des partenaires en \u00e2ge de procr\u00e9er; <strong>EI (tr\u00e8s fr\u00e9quents)<\/strong>: An\u00e9mie, fatigue\/\u00e9puisement, douleurs musculosquelettique, naus\u00e9es, constipation, dyspn\u00e9e, c\u00e9phal\u00e9e, \u00e9tourdissement, hypoxie, alanine aminotransf\u00e9rase augment\u00e9e, aspartate aminotransf\u00e9rase augment\u00e9e; <strong>P<\/strong>: 90 comprim\u00e9s pellicul\u00e9s \u00e0 40 mg; <strong>CR<\/strong>: A; <strong>Td\u2019a<\/strong>: MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, 6005 Lucerne, Suisse; (V2.0); CH-BEL-00013.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--4a2af53890e16143cad9fc9df06f452b\"><em>Avant de prescrire, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur <a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=68531\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>.<\/em><\/p>\n\n\n<div class=\"mhh-mcn-v1-links mhh-mcn-v1-links--a4b2e6dd9bc1e5063a3cb4413c58fb90\">\n    <a class=\"mhh-mcn-v1-link mhh-mcn-v1-link--9e8104a6f5eec9849dd3d04c4bebc2f7 mhh-mcn-v1-link--is-variation mhh-mcn-v1-link--button-custom\" href=\"https:\/\/www.swissmedicinfo-pro.ch\/showText.aspx?textType=FI&#038;lang=FR&#038;authNr=68531&#038;supportMultipleResults=1\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Information professionnelle de WELIREG\u00ae\">\n                    <span class=\"mhh-mcn-v1-link__label\">Information professionnelle de WELIREG\u00ae<\/span>\n                <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan) \u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 [&hellip;]<\/p>\n","protected":false},"author":202221,"featured_media":101015,"parent":96214,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":false,"isSticky":false},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"icon":null,"job_code":"","primary_tag":1608,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[],"tags":[1608],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[957],"ga4_page_businessunit":[963],"ga4_page_campaign":[],"ga4_page_content_purpose":[1535],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[1206],"ga4_page_product":[1216],"ga4_page_region":[1462],"ga4_page_therapeuticarea":[1497],"tx-therapeutic-area":[627,931],"tx-product":[1522],"tx-pathology":[],"tx-content-type":[1609],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-99413","page","type-page","status-publish","has-post-thumbnail","hentry","tag-kfi"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan) - MyMSD.ch FR<\/title>\n<meta name=\"robots\" content=\"noindex, nofollow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan) - MyMSD.ch FR\" \/>\n<meta property=\"og:description\" content=\"Information professionnelle abr\u00e9g\u00e9e de WELIREG\u00ae (Belzutifan) \u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. 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