{"id":97045,"date":"2024-10-11T15:31:36","date_gmt":"2024-10-11T15:31:36","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?page_id=97045"},"modified":"2026-05-21T14:15:46","modified_gmt":"2026-05-21T14:15:46","slug":"winrevair","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/winrevair\/","title":{"rendered":"Information professionnelle abr\u00e9g\u00e9e de WINREVAIR\u00ae (Sotatercept)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--2410d309fefde949e921ed2e409e778a\"><mark class=\"has-inline-color has-teal-500-color\">Information professionnelle abr\u00e9g\u00e9e de WINREVAIR<sup>\u00ae<\/sup> (Sotatercept)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--ab94c89795e4a74627bf95af7ef7e7b6\">\u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle (WINREVAIR\u00ae) disponible sous <a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=69787\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>.<\/p>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--444e0ec3e364babdfc0219a3583dca10\"><strong>WINREVAIR\u00ae: C:<\/strong> Sotatercept<strong>. I:<\/strong> En association avec un traitement standard de l\u2019hypertension art\u00e9rielle pulmonaire (HTAP), dans le traitement au long cours de l\u2019HTAP chez les adultes en classe fonctionnelle II, III et IV de l\u2019OMS. <strong>Po:<\/strong> <em>Adultes:<\/em> une fois toutes les 3 semaines en injection sous-cutan\u00e9e d\u00e9pend du poids corporel; d\u00e9terminer le taux d&rsquo;h\u00e9moglobine (Hb) et le nombre plaquettes avant la premi\u00e8re dose; dose initiale: 0,3 mg\/kg; avant d&rsquo;augmenter la dose jusqu&rsquo;\u00e0 la dose cible, v\u00e9rifier le taux d&rsquo;Hb et le nombre plaquettes; dose cible: 0,7 mg\/kg toutes les 3 semaines; ajustements posologiques en raison d&rsquo;une augmentation du taux d&rsquo;h\u00e9moglobine ou d&rsquo;une diminution du nombre plaquettes: contr\u00f4ler les taux d\u2019Hb et le nombre plaquettes au moins avant chaque dose lors les 5 premi\u00e8res doses; mode d\u2019administration: apr\u00e8s reconstitution, administrer par injection sous-cutan\u00e9e au niveau de l&rsquo;abdomen (\u00e0 au moins 5 cm du nombril), du haut du bras ou de la cuisse<em>.<\/em> <strong>CI:<\/strong> Hypersensibilit\u00e9 au principe actif\/excipients.<strong> Pr: <\/strong>\u00c9rythrocytose; Thrombop\u00e9nie s\u00e9v\u00e8re; Saignements graves; Toxicit\u00e9 embryof\u0153tale; Alt\u00e9ration de la fertilit\u00e9; Limitation des donn\u00e9es cliniques: aucun patient atteint d\u2019HTAP associ\u00e9 au VIH, \u00e0 l\u2019hypertension portale, \u00e0 la bilharziose ou \u00e0 la MVOP n\u2019a \u00e9t\u00e9 inclus. <strong>IA:<\/strong> Aucune \u00e9tude d&rsquo;interaction men\u00e9e. <strong>G\/A:<\/strong> Grossesse: non recommand\u00e9, contraception; Allaitement: non recommand\u00e9. <strong>EI (tr\u00e8s fr\u00e9quents):<\/strong> Thrombop\u00e9nie, h\u00e9moglobine augment\u00e9e, \u00e9tourdissement, c\u00e9phal\u00e9es, \u00e9pistaxis, diarrh\u00e9es, saignement des gencives, t\u00e9langiectasie, \u00e9ruption. <strong>P:<\/strong> Kit de 45 mg ou 60 mg poudre\/flacon et solvant pour pr\u00e9paration d&rsquo;une solution injectable disponible en 2 emballages: contenant 1 (ou 2) flacon de poudre, 1 (ou 2) seringue pr\u00e9remplie de solvant, 1 seringue doseuse, 1 (ou 2) adaptateur pour flacons, 1 aiguille d&rsquo;injection et 4 (ou 8) tampons alcoolis\u00e9s. <strong>CR:<\/strong> B. <strong>Td\u2019a:<\/strong> MSD Merck Sharp &amp; Dohme AG, B\u00fcrgenstrasse 8, 6005 Lucerne, Suisse. (V2.1); CH-SOT-00052.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p dir=\"ltr\" lang=\"fr-FR\" class=\"has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-link-color has-object-object-font-size wp-elements-e3944dd8fc3f524fce5ed87929002de1   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--5d80a8ff4f584dd5c90e1d220414eff8\"><em><em><em>Avant de prescrire, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur la page d&rsquo;accueil de Swissmedic<\/em><\/em> (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=69787\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/p>\n\n\n\n<p dir=\"ltr\" lang=\"fr-FR\" class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--741d0f7435d12eb3b3a72fbe1dae87f2\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Information professionnelle abr\u00e9g\u00e9e de WINREVAIR\u00ae (Sotatercept) \u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. Pour plus d\u2019informations, se r\u00e9f\u00e9rer \u00e0 [&hellip;]<\/p>\n","protected":false},"author":73172,"featured_media":0,"parent":96214,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mhh_sticky_footer_settings":{"entityId":0},"_mhh_sticky_footer_posts":"","_mhh_sticky_footer_expanded":false,"_mhh_mcn_text_direction":"","_mhh_mcn_language":"","_mhh_mcn_left_sidebar_settings":{"entityId":0},"_mhh_mcn_sidebar_settings":{"entityId":0},"mhh_mcn_side_navigation_style":{"fontSize":{"l":"","m":"","s":""},"lineHeight":{"l":1.5,"m":1.5,"s":1.5},"itemColor":"","hoverItemColor":"","currentItemColor":"","borderItemColor":"","backgroundItemHoverColor":"","themeColor":""},"_mhh_mcn_child_page_navigation":{"isActive":false,"isSticky":false},"hide_header":false,"show_top_bar":false,"hide_footer":false,"full_width_layout":false,"icon":null,"job_code":"","primary_tag":1608,"editor_notices":[],"mconnectHideShareThis":false,"footnotes":"","mconnectIsArchiveTemplate":false,"mconnectArchiveFiltersDisabled":false,"mconnectArchiveLockAllPresetFilters":false,"mconnectArchiveHidePageSubmenu":false,"mconnectArchiveShowParentPageOnly":false,"mconnectArchiveDefaultOrder":"DESC","mconnectArchiveDefaultOrderBy":"date","mconnectArchivePostsPerPage":12,"mconnectArchivePostTypes":[],"mconnectArchiveAllowFilterBy":["category","tx-content-type","tx-product","tx-pathology","tx-active-ingredient","tx-therapeutic-area"],"mconnectArchiveTaxonomyOrder":[],"mconnectArchiveFilterSorting":["active","is_keyword","is_date"],"mconnectArchiveContentItemStyle":{"showExcerpt":true,"showImage":true,"showIcon":false,"showPrimaryTag":true,"showBorder":false,"showDates":false,"showCta":true,"isCard":false,"hasBackground":false,"showMetadata":true},"mconnectArchiveLayout":{"type":"list","hasFeatured":false},"mconnectDynamicTaxonomyEntities":[],"mconnectArchiveTerms_category":[],"mconnectArchiveAllowTerms_category":[],"mconnectArchiveTerms_tx-content-type":[],"mconnectArchiveAllowTerms_tx-content-type":[],"mconnectArchiveTerms_tx-product":[],"mconnectArchiveAllowTerms_tx-product":[],"mconnectArchiveTerms_tx-pathology":[],"mconnectArchiveAllowTerms_tx-pathology":[],"mconnectArchiveTerms_tx-active-ingredient":[],"mconnectArchiveAllowTerms_tx-active-ingredient":[],"mconnectArchiveTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_tx-therapeutic-area":[],"mconnectArchiveAllowTerms_dynamic-taxonomy":[],"mconnectArchiveLegacyDefaultTermsApplied":false,"mconnectContentUpdatesPerPage":10,"mconnectContentUpdatesViewMoreUrl":"","mconnectContentUpdatesTerms_tx-content-type":[],"mconnectContentUpdatesTerms_tx-product":[],"mconnectContentUpdatesTerms_tx-pathology":[],"mconnectContentUpdatesTerms_tx-active-ingredient":[],"mconnectContentUpdatesTerms_tx-therapeutic-area":[],"sidebar_toogle":0,"sidebar_toogle_notification_warning":true,"sidebar_toogle_notification_alert":true,"content_expiration_sidebar_date":"","content_expiration_sidebar_expired_post_status":"","content_expiration_sidebar_redirection":""},"categories":[1607],"tags":[1608],"ga4_page_audience":[],"ga4_page_birn_id":[],"ga4_page_branding":[957],"ga4_page_businessunit":[962],"ga4_page_campaign":[],"ga4_page_content_purpose":[1535],"ga4_page_customer_journey_stage":[],"ga4_page_customer_specialty":[],"ga4_page_experience":[],"ga4_page_indication":[],"ga4_page_material_intent":[1206],"ga4_page_product":[1740],"ga4_page_region":[1462],"ga4_page_therapeuticarea":[1513],"tx-therapeutic-area":[1570],"tx-product":[1742],"tx-pathology":[],"tx-content-type":[1609],"tx-active-ingredient":[],"access":[],"user_status":[],"user_role":[],"class_list":["post-97045","page","type-page","status-publish","hentry","category-kfi","tag-kfi"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Information professionnelle abr\u00e9g\u00e9e de WINREVAIR\u00ae (Sotatercept) - MyMSD.ch FR<\/title>\n<meta name=\"robots\" content=\"noindex, nofollow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Information professionnelle abr\u00e9g\u00e9e de WINREVAIR\u00ae (Sotatercept) - MyMSD.ch FR\" \/>\n<meta property=\"og:description\" content=\"Information professionnelle abr\u00e9g\u00e9e de WINREVAIR\u00ae (Sotatercept) \u25bc Ce m\u00e9dicament fait l\u2019objet d\u2019une surveillance suppl\u00e9mentaire. 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