{"id":96889,"date":"2024-10-08T16:30:45","date_gmt":"2024-10-08T16:30:45","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?page_id=96889"},"modified":"2026-02-19T17:26:53","modified_gmt":"2026-02-19T17:26:53","slug":"adempas","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/adempas\/","title":{"rendered":"Information professionnelle abr\u00e9g\u00e9e d\u2019Adempas\u00ae \/ Adempas junior (riociguat)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--1bafccd3c93be2c4bb59861cbcc39047\"><mark class=\"has-inline-color has-teal-500-color\">Information professionnelle abr\u00e9g\u00e9e d\u2019Adempas<sup>\u00ae<\/sup> \/ Adempas junior (riociguat)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--29f94080d7fddc1ee37f2a922c8d339e\"><strong>Adempas\u00ae \/ Adempas junior:<\/strong> <strong>PA:<\/strong> Riociguat; <strong>I:<\/strong> Adultes: am\u00e9lioration de la capacit\u00e9 de performance physique en cas d\u2019hypertension pulmonaire thromboembolique chronique (HPTEC) non op\u00e9rable, en cas d\u2019HPTEC persistante\/r\u00e9cidivante apr\u00e8s traitement chirurgical ou en cas d\u2019hypertension art\u00e9rielle pulmonaire (HAP) en classe fonctionnelle OMS II et III; Enfants et Adolescents: HAP en classe fonctionnelle OMS II et III; <strong>Po:<\/strong> Administr\u00e9 par voie orale: comprim\u00e9 ou granul\u00e9s pour suspension buvable; Adultes: Dose initiale: 0.5 mg ou 1.0 mg 3x par jour, augmentation progressive de la dose par paliers de 0.5 mg jusqu\u2019\u00e0 une dose maximale de 2.5 mg 3x par jour; Instructions posologiques particuli\u00e8res: Avec un soin particulier chez des patients \u00e2g\u00e9s (\u226565 ans), chez des patients pr\u00e9sentant une insuffisance h\u00e9patique mod\u00e9r\u00e9e (Child Pugh B), chez les patients pr\u00e9sentant une insuffisance r\u00e9nale l\u00e9g\u00e8re, mod\u00e9r\u00e9e ou s\u00e9v\u00e8re (clairance de la cr\u00e9atinine de 80 \u00e0 15 ml\/min), chez des patients prenant des doses stables d\u2019inhibiteurs \u00abmulti-pathway\u00bb puissants du CYP\/de la P-glycoprot\u00e9ine (P-gp) et de la breast cancer resistance protein (BCRP), chez les fumeurs; <strong><em>Pour d&rsquo;autres indications et les dosages correspondants pour les adultes et les patients p\u00e9diatriques, veuillez vous r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle;<\/em><\/strong> <strong>CI:<\/strong> Grossesse et allaitement; association avec: d\u00e9riv\u00e9s nitr\u00e9s, donneurs de monoxyde d\u2019azote, inhibiteurs sp\u00e9cifiques de la phosphodiest\u00e9rase-5 et inhibiteurs non sp\u00e9cifiques de la phosphodiest\u00e9rase, stimulateurs de la guanylate cyclase soluble; Hypertension pulmonaire associ\u00e9e \u00e0 des pneumonies interstitielles idiopathiques; <strong>Pr:<\/strong> Occlusion veineuse pulmonaire; Risque h\u00e9morragique globalement accru et du syst\u00e8me respiratoire; Effet vasodilatateur, baisse de la tension art\u00e9rielle possible; Risque accru d\u2019ost\u00e9oporose; Pas \u00e9tudi\u00e9: Association avec des antagonistes des r\u00e9cepteurs de l\u2019endoth\u00e9line ou des prostano\u00efdes chez HPTEC, chez les adultes et les 12 \u00e0 &lt;18 ans avec pression systolique &lt;95 mmHg au d\u00e9but du traitement et les 6 \u00e0 &lt;12 ans avec une pression systolique &lt;90 mmHg, insuffisance h\u00e9patique s\u00e9v\u00e8re, clairance de la cr\u00e9atinine &lt;15 ml\/min et chez les patients dialys\u00e9s, chez les enfants et les adolescents de moins de 18 ans dont la fonction h\u00e9patique ou r\u00e9nale est r\u00e9duite; Comprim\u00e9s contiennent lactose; <strong>IA:<\/strong> Inducteurs du CYP3A4, inhibiteurs \u00abmulti-pathway\u00bb puissants du CYP et de la P-gp\/BCRP et autres inhibiteurs puissants du CYP et de la P-gp\/BCRP, inhibiteurs de la pompe \u00e0 protons, antiacides; Risque d\u2019h\u00e9morragies accru lors de l\u2019utilisation avec des anticoagulants, des antiagr\u00e9gants plaquettaires; Exposition r\u00e9duite chez les fumeurs; <strong>G\/A:<\/strong> Contre-indiqu\u00e9; <strong>EI:<\/strong> Tr\u00e8s fr\u00e9quent: c\u00e9phal\u00e9es, vertiges, dyspepsie, naus\u00e9es, diarrh\u00e9e, vomissements, \u0153d\u00e8mes p\u00e9riph\u00e9riques; <strong>P:<\/strong> 42 et 84 comprim\u00e9s pellicul\u00e9s de 0.5 mg \/ 1.0 mg \/ 1.5 mg \/ 2.0 mg \/ 2.5 mg; Granul\u00e9s pour suspension buvable: flacon en verre avec 10.5 g de granul\u00e9s avec seringue \u00e0 eau et seringues doseuses; <strong>CR:<\/strong> B; <strong>Td\u2019a:<\/strong> Bayer (Schweiz) AG, Uetlibergstrasse 132, 8045 CH-Zurich; (V5.0); CH-ADE-00030.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color has-gray-800-color has-text-color has-link-color wp-elements-b6ea4690e52e1b39eb4ed2e868fb3d67   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--4cab8d3ce57aea4c6d4e85d25c73ba21\"><em>Avant de prescrire, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur la page d&rsquo;accueil de Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=62903\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Information professionnelle abr\u00e9g\u00e9e d\u2019Adempas\u00ae \/ Adempas junior (riociguat) Adempas\u00ae \/ Adempas junior: PA: Riociguat; I: Adultes: am\u00e9lioration de la capacit\u00e9 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