{"id":100043,"date":"2025-04-28T13:15:43","date_gmt":"2025-04-28T13:15:43","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?page_id=100043"},"modified":"2026-02-04T09:55:29","modified_gmt":"2026-02-04T09:55:29","slug":"zerbaxa","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/zerbaxa\/","title":{"rendered":"Information professionnelle abr\u00e9g\u00e9e de ZERBAXA\u00ae"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--2885029e84c3fa80345063d1d59d6e52\"><mark class=\"has-inline-color has-teal-500-color\">Information professionnelle abr\u00e9g\u00e9e de ZERBAXA<sup>\u00ae<\/sup> (ceftolozane\/tazobactam)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--b7b57d1c60c60e3e25b334e4bb953909\"><strong>ZERBAXA<sup>\u00ae<\/sup>: PA : <\/strong>ceftolozane 1 g\/tazobactam 0,5 g<em>. <\/em><strong>I <\/strong>(adultes) <strong>: <\/strong>traitement des infections suivantes, dues de mani\u00e8re av\u00e9r\u00e9e ou pr\u00e9sum\u00e9e \u00e0 des germes reconnus sensibles : Infections intra-abdominales compliqu\u00e9es (IIAc), en association avec le m\u00e9tronidazole; Infections des voies urinaires compliqu\u00e9es (IVUc), y compris py\u00e9lon\u00e9phrite; Pneumonie nosocomiale, y compris pneumonie acquise sous ventilation m\u00e9canique (PAVM). <strong>Po: <\/strong>Perfusion i.v. de 1 h toutes les 8 h<em>. Clairance de la cr\u00e9atinine (ClCr) &gt;50 ml\/min : <\/em>IIAc: 1,5 g (1 g de ceftolozane\/0,5 g de tazobactam), 4-14 jours; IVUc, y compris py\u00e9lon\u00e9phrite: 1,5 g (1 g de ceftolozane\/0,5 g de tazobactam), 7 jours; Pneumonie nosocomiale, y compris PAVM: 3 g (2 g de ceftolozane\/1 g de tazobactam), 8-14 jours. Chez les patients atteints d&rsquo;insuffisance r\u00e9nale mod\u00e9r\u00e9e ou s\u00e9v\u00e8re, ainsi que chez les patients en insuffisance r\u00e9nale terminale sous h\u00e9modialyse, la dose doit \u00eatre adapt\u00e9e comme indiqu\u00e9 dans l\u2019information professionnelle compl\u00e8te. <strong>Pour d&rsquo;autres indications et les dosages correspondants pour les adultes et les patients p\u00e9diatriques, veuillez vous r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle.<\/strong> &nbsp;<strong>CI: <\/strong>Hypersensibilit\u00e9 aux substances actives, \u00e0 l\u2019un des excipients ou aux antibiotiques de la classe des c\u00e9phalosporines. Hypersensibilit\u00e9 s\u00e9v\u00e8re \u00e0 d\u2019autres antibiotiques de la classe des b\u00eata-lactamines. <strong>Pr: <\/strong>La survenue d&rsquo;une r\u00e9action allergique grave, pouvant \u00e9galement \u00eatre li\u00e9e au syndrome de Kounis, n\u00e9cessite l&rsquo;arr\u00eat du m\u00e9dicament et la mise en place de mesures adapt\u00e9es.. Des r\u00e9actions cutan\u00e9es graves aux m\u00e9dicaments (SCAR) telles que le syndrome de Stevens-Johnson, n\u00e9crolyse \u00e9pidermique toxique, exanth\u00e8me m\u00e9dicamenteux avec \u00e9osinophilie et sympt\u00f4mes syst\u00e9miques (DRESS), \u00e9ryth\u00e8me polymorphe et la pustulose exanth\u00e9matique aigu\u00eb g\u00e9n\u00e9ralis\u00e9e (AGEP)&nbsp;: cesser imm\u00e9diatement le ZERBAXA<sup>\u00ae<\/sup> et envisager une th\u00e9rapie alternative. Diarrh\u00e9es pendant ou apr\u00e8s l\u2019administration : envisager un diagnostic de colite associ\u00e9e aux antibact\u00e9riens ou de colite pseudo-membraneuse. L\u2019utilisation peut entra\u00eener une prolif\u00e9ration de micro-organismes non sensibles. En cas de surinfection pendant le traitement, une th\u00e9rapie ad\u00e9quate doit \u00eatre mise en place. Efficacit\u00e9 tr\u00e8s limit\u00e9e sur certains organismes \u00e0 Gram positif et ana\u00e9robies (des substances antibact\u00e9riennes suppl\u00e9mentaires doivent \u00eatre envisag\u00e9es). Zerbaxa est consid\u00e9r\u00e9 comme riche en sodium, \u00e0 tenir en compte chez les patients suivant un r\u00e9gime pauvre en sodium. <strong>IA: <\/strong>Les inhibiteurs de l\u2019OAT1 et de l\u2019OAT3 peuvent augmenter les concentrations plasmatiques de tazobactam. Aucune interaction avec les substrats, inhibiteurs et inducteurs des enzymes du CYP450. <strong>G\/A: <\/strong>Non recommand\u00e9. <strong>EI:<\/strong><em>IIAc<\/em><em>\/IVUc, y compris py\u00e9lon\u00e9phrite: fr\u00e9quents:<\/em> naus\u00e9es, c\u00e9phal\u00e9es, diarrh\u00e9e, fi\u00e8vre, constipation, insomnie, vomissement, hypokali\u00e9mie, ALAT augment\u00e9e, ASAT augment\u00e9e, an\u00e9mie, thrombocytose, douleur abdominale, anxi\u00e9t\u00e9, sensation vertigineuse, hypotension, fibrillation auriculaire, rash, r\u00e9actions au niveau du site de perfusion. <em>Pneumonie nosocomiale, y compris PAVM<\/em><em>: fr\u00e9quents:<\/em> diarrh\u00e9e, vomissements, colite \u00e0 <em>Clostridium difficile<\/em>, ALAT augment\u00e9e, ASAT augment\u00e9e, transaminases augment\u00e9es, anomalies des param\u00e8tres h\u00e9patiques, phosphatase alcaline sanguine augment\u00e9e, gamma-glutamyltransf\u00e9rase augment\u00e9e, h\u00e9morragie intracr\u00e2nienne, insuffisance\/d\u00e9faillance r\u00e9nale. <strong>P: <\/strong>10 flacons de 1,5 g. <strong>CR: <\/strong>A. <strong>Td\u2019a<\/strong><strong>:<\/strong> MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, 6005 Lucerne, Suisse. (V5.0); CH-ZER-00009.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--cbd1a0eecd81f82722f0f448a49fedf6\"><em>Avant de prescrire, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur la page d\u2019accueil de Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=65472\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Information professionnelle abr\u00e9g\u00e9e de ZERBAXA\u00ae (ceftolozane\/tazobactam) ZERBAXA\u00ae: PA : ceftolozane 1 g\/tazobactam 0,5 g. 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