{"id":100035,"date":"2025-04-28T13:13:15","date_gmt":"2025-04-28T13:13:15","guid":{"rendered":"https:\/\/www.mymsd.ch\/fr\/?page_id=100035"},"modified":"2026-02-04T09:41:43","modified_gmt":"2026-02-04T09:41:43","slug":"pifeltro","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/fr\/succinctstatement\/pifeltro\/","title":{"rendered":"Information professionnelle abr\u00e9g\u00e9e de PIFELTRO\u00ae"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-teal-500-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--1de2b825d39d38f8e0c30f8d434d1a82\">Information professionnelle abr\u00e9g\u00e9e de PIFELTRO<sup>\u00ae<\/sup> (doravirine)<\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--1b12b91e94c4bc6928d3b389784d228b\"><strong>PIFELTRO<sup>\u00ae<\/sup>:<\/strong> <strong>PA: <\/strong>Doravirine. <strong>I:<\/strong> En association avec d\u2019autres m\u00e9dicaments antir\u00e9troviraux, pour le traitement de l\u2019infection par le virus de l\u2019immunod\u00e9ficience humaine de type 1 (VIH-1) chez des adultes, na\u00effs de traitement, ou pour le remplacement du traitement antir\u00e9troviral actuel chez des patients chez lesquels on n\u2019a d\u00e9tect\u00e9 aucune des mutations du VIH-1 associ\u00e9es \u00e0 une r\u00e9sistance \u00e0 la doravirine, et qui n\u2019ont pr\u00e9sent\u00e9 aucun \u00e9chec th\u00e9rapeutique virologique par le pass\u00e9, et qui sont virologiquement contr\u00f4l\u00e9s (taux d\u2019ARN du VIH-1 &lt;50 copies\/ml) depuis au moins 6 mois par un traitement antir\u00e9troviral stable. <strong>Po: <\/strong>1 comprim\u00e9 de 100&nbsp;mg 1x par jour en association avec d\u2019autres m\u00e9dicaments antir\u00e9troviraux. <strong><em>Pour d&rsquo;autres indications et les dosages correspondants pour les adultes et les patients p\u00e9diatriques, veuillez vous r\u00e9f\u00e9rer \u00e0 l&rsquo;information professionnelle.<\/em><\/strong> <strong>CI: <\/strong>Hypersensibilit\u00e9 aux principes actifs \/ excipients. Association avec des m\u00e9dicaments qui sont de puissants inducteurs de l\u2019enzyme CYP3A tels que enzalutamide, carbamaz\u00e9pine, oxcarbaz\u00e9pine, ph\u00e9nobarbital, ph\u00e9nyto\u00efne, rifampicine, rifapentine, mitotane, lumacaftor, millepertuis. <strong>Pr:<\/strong> Le risque de transmission sexuelle du VIH ne peut \u00eatre exclu si le TAR prescrit n\u2019est pas pris r\u00e9guli\u00e8rement et\/ou si la suppression virologique n\u2019est pas atteinte et maintenue. Des r\u00e9actions cutan\u00e9es s\u00e9v\u00e8res (dont le syndrome de Stevens-Johnson\/la n\u00e9crolyse \u00e9pidermique toxique) ont \u00e9t\u00e9 rapport\u00e9es. Un syndrome de restauration immunitaire (y compris des maladies auto-immunes) peut survenir chez les patients trait\u00e9s par une association d\u2019antir\u00e9troviraux. Contient du lactose. D\u00e9pister les patients infect\u00e9s par le VIH-1 par rapport au VHB avant le d\u00e9but du traitement; surveiller les patients atteints du VIH et pr\u00e9sentant une co-infection par le VHB \/ VHC \u00e0 la recherche d\u2019effets ind\u00e9sirables h\u00e9patiques. Continuer \u00e0 surveiller les patients \u00e0 la recherche d\u2019infections opportunistes et autres complications d\u2019une infection par le VIH. En raison du risque d\u2019ost\u00e9on\u00e9crose, instruire les patients de consulter le m\u00e9decin en cas de troubles et douleurs articulaires, de raideur articulaire ou de difficult\u00e9s motrices. <strong>IA:<\/strong> Inducteurs et inhibiteurs de l\u2019enzyme CYP3A. Si la co-administration d\u2019inducteurs mod\u00e9r\u00e9s du CYP3A est in\u00e9vitable, augmenter la dose. Prudence lors de la co-administration de la doravirine avec des m\u00e9dicaments qui sont des substrats sensibles du CYP3A pr\u00e9sentant une marge th\u00e9rapeutique \u00e9troite. <strong>G\/A:<\/strong> Non recommand\u00e9. <strong>EI: <\/strong><em>Fr\u00e9quents:<\/em> r\u00eaves anormaux, insomnie, c\u00e9phal\u00e9es, sensations vertigineuses, somnolence, naus\u00e9es, diarrh\u00e9e, flatulences, douleurs abdominales, vomissements, rash, fatigue, augmentation de l\u2019alanine aminotransf\u00e9rase. <strong>P: <\/strong>30&nbsp;comprim\u00e9s pellicul\u00e9s de 100&nbsp;mg. <strong>CR: <\/strong>A. <strong>Td\u2019a:<\/strong> MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, 6005 Lucerne, Suisse; (V3.0); CH-DOV-00009.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--f61c6feb988bf17239c0aefabc320ece\"><em>Avant de prescrire, veuillez consulter l\u2019information professionnelle compl\u00e8te publi\u00e9e sur la page d&rsquo;accueil de Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=FR&amp;authNr=67065\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Information professionnelle abr\u00e9g\u00e9e de PIFELTRO\u00ae (doravirine) PIFELTRO\u00ae: PA: Doravirine. 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