{"id":123770,"date":"2025-08-25T10:29:22","date_gmt":"2025-08-25T10:29:22","guid":{"rendered":"https:\/\/www.mymsd.ch\/de\/?page_id=123770"},"modified":"2026-02-04T09:35:37","modified_gmt":"2026-02-04T09:35:37","slug":"isentress","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/de\/succinctstatement\/isentress\/","title":{"rendered":"KFI ISENTRESS\u00ae"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--8d2066572e4ea129dd8746c9881edcdd\"><mark class=\"has-inline-color has-teal-500-color\">Kurzfachinformation ISENTRESS\u00ae (Raltegravir)<\/mark><\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--506fdbfcb9cfaf31f7e2e5c5015bd26e\"><strong>ISENTRESS\u00ae (Raltegravir): W:<\/strong> Raltegravir.<strong> I:<\/strong> Zur Behandlung einer Infektion mit dem humanen Immunodefizienzvirus (HIV-1), in Kombination mit antiretroviralen AM. <strong>D: <\/strong><em>Erw:<\/em> 600 mg: 1x t\u00e4gl. 1200 mg (2&#215;600 mg) bei behandlungsnaiven Patienten oder vorbehandelten Patienten, stabil unter 400 mg 2x t\u00e4gl., ohne vorangegangenes virologisches Therapieversagen und w\u00e4hrend mind. 6 Mt virologisch supprimiert unter 400 mg 2x t\u00e4gl. als Teil der ersten HIV Behandlung. 400 mg: 2x t\u00e4gl. bei behandlungsnaiven oder vorbehandelten Patienten. Formulierungen sind nicht bio\u00e4quivalent, daher darf die 600 mg nicht durch eine 400 mg Tablette ersetzt werden. <em>Kdr\/ Jugendl.:<\/em> 400 mg: 2x t\u00e4gl., falls KG \u2265 25 kg.<em> Beeintr\u00e4chtigte Nierenfunktion:<\/em> Keine Dosisanpassung.<em> Leicht bis moderat beeintr\u00e4chtigte Leberfunktion:<\/em> Keine Dosisanpassung. <strong>KI:<\/strong> \u00dcberempfindlichkeit gegen\u00fcber Inhaltsstoffe. <strong>WH:<\/strong> Risiko einer sexuellen \u00dcbertragung von HIV kann nicht ausgeschlossen werden, wenn die verordnete ART nicht regelm\u00e4ssig eingenommen wird und\/oder die virale Suppression nicht erreicht und aufrechterhalten wird. <em>HIV und Hepatitis-B-Virus(HBV)- oder Hepatitis-C-Virus(HCV)-Koinfektion:<\/em> Begrenzte Daten vorhanden. <em>Osteonekrose:<\/em> F\u00e4lle berichtet; bei Gelenkbeschwerden und -schmerzen, Gelenksteife oder Schwierigkeiten bei Bewegungen Arzt aufsuchen. <em>Schwerwiegende Hautreaktionen und \u00dcberempfindlichkeitsreaktionen:<\/em> Schwerwiegende, potenziell lebensbedrohliche und t\u00f6dliche Hautreaktionen bei gleichzeitiger Einnahme mit Arzneimitteln, welche mit solchen Reaktionen assoziiert sind m\u00f6glich (Stevens-Johnson Syndrom und toxisch-epidermaler Nekrolyse) &#8211; sofortiges Absetzen und ad\u00e4quate Behandlung kann erforderlich sein. <strong>DDI: <\/strong>400 mg: Vorsicht bei starken UGT1A1-Induktoren. 600 mg: Koadministration mit UGT1A1 Inhibitoren und starken UGT1A1 Induktoren nicht empfohlen. <em>Antazida<\/em> (Al- und\/oder Mg-enthaltend; sowie CaCO3-enthaltend bei 600 mg): Koadministration nicht empfohlen. <strong>S\/S: <\/strong>400 mg 2x t\u00e4gl.: Kann w\u00e4hrend der Schwangerschaft angewendet werden, falls klinisch notwendig; 600 mg: Begrenzte Daten vorhanden. Vom Stillen wird abgeraten. <strong>UAW:<\/strong> 400 mg und 600 mg: Vergleichbare H\u00e4ufigkeit schwerwiegender klin. UAWs. <em>Vorbehandelte Patienten:<\/em> Arzneimittelbedingt \u2265 2 %: Diarrhoe, Kopfschmerz. <em>Behandlungsnaive Patienten:<\/em> Arzneimittelbedingt \u2265 2 %: Diarrhoe, \u00dcbelkeit, Erm\u00fcdung, Schwindel, Kopfschmerz, Schlaflosigkeit, Hautausschlag, makulopapul\u00f6ser Ausschlag. <strong>P:<\/strong> Flaschen zu 60 St\u00fcck: <em>Filmtabletten: <\/em>400 mg und 600 mg. <strong>AK:<\/strong> A. <strong>Z:<\/strong> MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, 6005 Luzern, Schweiz. (V3.0); CH-MFA-00004.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--e77178bc154d446f8e20aba947276e9c\"><mark class=\"has-inline-color has-gray-700-color\"><em>Konsultieren Sie bitte vor einer Verschreibung die vollst\u00e4ndige Fachinformation, publiziert auf der Homepage von Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=DE&amp;authNr=58267\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/mark><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kurzfachinformation ISENTRESS\u00ae (Raltegravir) ISENTRESS\u00ae (Raltegravir): W: Raltegravir. 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