{"id":121495,"date":"2025-04-28T13:17:28","date_gmt":"2025-04-28T13:17:28","guid":{"rendered":"https:\/\/www.mymsd.ch\/de\/?page_id=121495"},"modified":"2026-02-04T10:07:48","modified_gmt":"2026-02-04T10:07:48","slug":"prevymis","status":"publish","type":"page","link":"https:\/\/www.mymsd.ch\/de\/succinctstatement\/prevymis\/","title":{"rendered":"KFI PREVYMIS\u00ae"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-border-color has-has-red-border-color-border-color has-teal-500-color has-text-color  mhh-mcn-v1-heading mhh-mcn-v1-heading--9a9d5eef50760928464a93616c210370\">Kurzfachinformation PREVYMIS<sup>\u00ae<\/sup> (Letermovir)<\/h1>\n\n\n\n<p class=\"has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--cfda6a36c4bf976619835b3e3928be18\"><strong>PREVYMIS\u00ae: W: <\/strong>Letermovir.<strong> I: <\/strong><em>Erwachsene:<\/em> Prophylaxe von Cytomegalovirus (CMV) Infektionen oder Erkrankungen bei CMV-seropositiven Empf\u00e4ngern [R+] einer allogenen h\u00e4matopoetischen Stammzelltransplantation (HSZT). <strong>D:<\/strong><em> Erwachsene:<\/em> 480 mg 1x t\u00e4glich, oral oder intraven\u00f6s; Beginn sp\u00e4testens 28 Tage nach HSZT, Weiterf\u00fchrung bis maximal 200 Tage nach HSZT; drei Darreichungsformen: Filmtabletten, Granulat im Beutel (oral, gemischt mit weicher Nahrung oder \u00fcber nasogastrale oder Gastrostomie-Sonde verabreicht), Konzentrat f\u00fcr Infusionsl\u00f6sung; Infusionsl\u00f6sung nur anwenden, wenn keine orale Therapie m\u00f6glich ist; das Konzentrat vor der Verabreichung verd\u00fcnnen und den gesamten Inhalt i.v. \u00fcber 60 Minuten langsam verabreichen; nur als i.v. Infusion durch einen sterilen 0,2 oder 0,22 \u03bcm Inline-Filter aus Polyethersulfon (PES); nicht als Schnellinfusion oder Bolus, verabreichen; bei gleichzeitiger Gabe mit Ciclosporin: Prevymis auf 240 mg einmal t\u00e4glich reduzieren.<strong><em> Weitere Indikationen und die dazugeh\u00f6rigen Dosierungen f\u00fcr Erwachsene und p\u00e4diatrische Patienten entnehmen Sie bitte der Fachinformation.<\/em><\/strong> <strong>KI:<\/strong> \u00dcberempfindlichkeit gegenu\u0308ber Wirk- \/Hilfsstoffe; gleichzeitige Gabe von Pimozid, Ergotalkaloiden, Johanniskraut (<em>Hypericum perforatum<\/em>) oder Ciclosporin in Kombination mit Dabigatran, Atorvastatin, Simvastatin, Rosuvastatin, Pitavastatin. <strong>WH:<\/strong> Die Sicherheit und Wirksamkeit von Letermovir wurden bei Patienten mit einem negativen CMV-DNA-Testergebnis vor Einleitung der Prophylaxe nachgewiesen. Die CMV-DNA wurde w\u00f6chentlich bis Woche 14 nach Transplantation kontrolliert und anschliessend alle 2 Wochen bis Woche 24. Nicht empfohlen bei m\u00e4ssiger Einschr\u00e4nkung der Leberfunktion in Kombination mit m\u00e4ssiger oder schwerer Einschr\u00e4nkung der Nierenfunktion, bei schwerer Einschr\u00e4nkung der Leberfunktion (Child-Pugh-Klasse C), bei Nierenerkrankung im Endstadium (CrCl &lt;10ml\/min) oder Dialysepatienten; Risiko im Zusammenhang mit Hilfsstoff Hydroxypropylbetadex in intraven\u00f6ser Formulierung; Risiko von unerw\u00fcnschten Reaktionen oder einer Verminderung der therapeutischen Wirkung aufgrund von Arzneimittelinteraktionen. <strong>DDI: <\/strong>Die Kombination von Ciclosporin und Letermovir kann zu st\u00e4rker ausgepr\u00e4gten oder zus\u00e4tzlichen Wirkungen auf gleichzeitig angewendete Arzneimittel f\u00fchren im Vergleich zur alleinigen Gabe von Letermovir. Die gemeinsame Anwendung von PREVYMIS\u00ae mit starken und moderaten Induktoren von Transportern (z.B. P-gp) und\/oder Enzymen (z.B. UGTs) wird nicht empfohlen, da dies zu einem subtherapeutischen Plasmaspiegel von Letermovir f\u00fchren kann. Letermovir ist ein Inhibitor von OATP1B1\/3-Transportern und kann zu einem klinisch relevanten Anstieg der Plasmakonzentrationen von gemeinsam angewendeten Substraten von OATP1B1\/3 f\u00fchren. Die gleichzeitige Anwendung von PREVYMIS\u00ae mit Inhibitoren der OATP1B1\/3-Transporter kann zu erh\u00f6hten Plasmakonzentrationen von Letermovir f\u00fchren. Letermovir ist ein moderater Induktor von Enzymen und Transportern; diese Induktion kann die Plasmakonzentrationen von einigen metabolisierten und transportierten Arzneimitteln senken. Letermovir ein moderater Inhibitor von CYP3A: Die Anwendung von PREVYMIS\u00ae kann zu klinisch relevanten Erh\u00f6hungen der Plasmakonzentrationen von gemeinsam angewendeten Substraten von CYP3A f\u00fchren. Letermovir kann die Exposition von CYP2C9- und\/oder CYP2C19-Substraten verringern, so dass m\u00f6glicherweise subtherapeutische Konzentrationen erreicht werden. Letermovir ist ein Induktor intestinalen P-gps: Die Anwendung von PREVYMIS\u00ae kann die Plasmakonzentrationen gemeinsam angewendeter Arzneimittel, f\u00fcr die der intestinale P-gp-Transport eine wichtige Rolle spielt in klinisch bedeutsamem Ausmass verringern. Vorsicht bei gleichzeitiger Verabreichung von PREVYMIS\u00ae und Arzneimitteln, die \u00fcber CYP2B6, CYP2C8 und UGT1A1 metabolisiert, \u00fcber den renalen Transporter OAT3 oder von BCRP, OATP2B1 transportiert werden.<strong> S\/S: <\/strong>Schwangerschaft: nicht empfohlen; nicht stillen. <strong>UAW:<\/strong> <em>H\u00e4ufig: <\/em>\u00dcbelkeit, Diarrh\u00f6, Erbrechen. <strong>P: <\/strong><em>Filmtabletten:<\/em> 240 mg und 480 mg \u00e0 28 Tabletten; <em>Granulat im Beutel: <\/em>30 Beutel \u00e0 20 mg oder 120 mg; <em>Durchstechflasche:<\/em> 240 mg \/ 12 ml; 480 mg \/ 24 ml. <strong>AK: <\/strong>A. <strong>Z:<\/strong> MSD Merck Sharp &amp; Dohme AG, Werftestrasse 4, Luzern, Schweiz; (V6.0); CH-CYT-00006.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-gray-300-color has-alpha-channel-opacity has-gray-300-background-color has-background\" \/>\n\n\n\n<p class=\"has-object-object-font-size has-border-color has-has-red-border-color-border-color   mhh-mcn-v1-paragraph mhh-mcn-v1-paragraph--eaf57a1869bfc94042539c68fda9a990\"><em>Konsultieren Sie bitte vor einer Verschreibung die vollst\u00e4ndige Fachinformation, publiziert auf der Homepage von Swissmedic (<a href=\"https:\/\/www.swissmedicinfo-pro.ch\/ShowText.aspx?textType=FI&amp;lang=DE&amp;authNr=69867\" target=\"_blank\" rel=\"noreferrer noopener\">www.swissmedicinfo-pro.ch<\/a>).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kurzfachinformation PREVYMIS\u00ae (Letermovir) PREVYMIS\u00ae: W: Letermovir. 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